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MAPK3 — RHOA

Pathways - manually collected, often from reviews:

• BioCarta trefoil factors initiate mucosal healing: RhoA (RHOA) → ERK1 (MAPK3) (modification, activates)
• NCI Pathway Database S1P2 pathway: Erk1-2 (MAPK3/MAPK1) → RhoA (RHOA) (modification, collaborate) An et al., J Biol Chem 2000, Arikawa et al., J Biol Chem 2003, Gonda et al., Biochem J 1999
  Evidence: mutant phenotype, assay
• NCI Pathway Database IL2-mediated signaling events: Erk1-2-active (MAPK3/MAPK1) → RHOA/GTP complex (RHOA) (transcription, activates) Satoh et al., J Biol Chem 1992, Arnaud et al., Biochem J 2004, Shibuya et al., Cell 1992*, Kawahara et al., Proc Natl Acad Sci U S A 1995*
  Evidence: mutant phenotype, reporter gene, other species

Text-mined interactions from Literome

Vial et al., Cancer Cell 2003 (Colonic Neoplasms...) : ERK-MAPK signaling coordinately regulates activity of Rac1 and RhoA for tumor cell motility
Calleros et al., Apoptosis 2006 : Finally, overexpression of the dominant negative N19RhoA inhibited p38 MAPK phosphorylation and apoptosis induced by low cholesterol levels
Khwaja et al., Kidney Int 2006 : GGTI 298 increased cytosolic expression of RhoA, prevented RhoA activation, and inhibited the activation of Erk1/2 and the survival protein Akt
Chapados et al., Circ Res 2006 (Disease Progression...) : Indeed, SMCs on denatured collagen possessed higher levels of RhoA activity than those on native collagen, and blocking RhoA or ROCK activities attenuated SMC spreading, ERK1/2 activity, and TN-C expression in SMCs on denatured collagen
Horowitz et al., Am J Physiol Gastrointest Liver Physiol 2007 (Crohn Disease...) : The RhoA inhibitor C3 exoenzyme and the ROCK inhibitor Y-27632 both attenuated TNF-alpha/lipopolysaccharide induced MAPK activation and blocked AR expression in HIMEC
Yano et al., Circ Res 2007 (Inflammation) : However, DN-RhoA and DN-Cdc42 activated p38 MAPK , but not ERK1/2
Zeidan et al., Cardiovasc Res 2008 (Cardiomegaly) : Leptin induced cardiomyocyte hypertrophy involves selective caveolae and RhoA/ROCK dependent p38 MAPK translocation to nuclei
Spindler et al., J Immunol 2010 (Disease Models, Animal...) : Several intracellular signaling pathways, such as p38MAPK activation and RhoA inhibition , have been demonstrated to be altered following autoantibody binding and to be causally involved in loss of keratinocyte cohesion
Shatanawi et al., Am J Physiol Cell Physiol 2011 : ANG II also elevates active RhoA levels and induces phosphorylation of p38 MAPK
Moey et al., J Pharmacol Exp Ther 2011 (Cardiomegaly) : These results demonstrate a potent inhibitory effect of ginseng against leptin induced cardiac hypertrophy, an effect associated with prevention of p115RhoGEF-RhoA/ROCK dependent p38 MAPK activation
Yang et al., PloS one 2012 (MAP Kinase Signaling System) : The results revealed that Zol markedly down-regulated active RhoA stimulated by Ang II and inhibited the phosphorylation of Erk1/2 and JNK
Li et al., Cell death & disease 2013 : The inhibited RhoA/ROCK1 signalling enhanced the phosphorylation of Erk1/2 in a Mek1/2 independent manner