Gene interactions and pathways from curated databases and text-mining

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PIK3R1 — RHOA

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Cozzolino et al., Mol Biol Cell 2003 : The deleted mutant also inhibits the PI3K dependent RhoA activation ensuing receptor activation
Viswambharan et al., Circ Res 2004 : In conclusion, rHDL inhibits thrombin induced human endothelial TF expression through inhibition of RhoA and activation of PI3K but not Akt/eNOS
Jiang et al., Mol Cell Biol 2004 (Cell Transformation, Neoplastic...) : Ectopic expression of RhoB, but not the close relative RhoA , inhibits Ras, PI3K , and Akt induction of transformation, migration, and invasion and induces apoptosis and anoikis
Teusch et al., J Immunol 2004 : In contrast to previous studies, identifying Rac1-PI3K as an upstream element in TLR2 initiated response to NF-kappaB, PI3K signaling was not required for RhoA or PKCzeta activity
Da Silva et al., Nat Neurosci 2005 : PMGS induces axon specification by enhancing TrkA activity locally, which triggers phosphatidylinositol-3-kinase (PI3K)- and Rac1 dependent inhibition of RhoA signaling and the consequent actin depolymerization in one neurite only
Raghu et al., J Virol 2007 (Herpesviridae Infections) : RhoA-GTPase activation was inhibited by PI3-K inhibitors, demonstrating that PI3-K is upstream to RhoA-GTPase
Meng et al., Br J Cancer 2009 (Adenocarcinoma...) : The PI3K inhibitor, LY294002, further blocked the expression of MMP9 and RhoA
Tiwari et al., J Gen Virol 2010 : We also show that inhibition of PI3K signalling also affected RhoA activation required for HSV-1 entry into certain cell types
Zeidan et al., Mol Cell Biochem 2011 : Our results demonstrate a critical role for PI3K/mTOR/p70 ( S6K ) in leptin induced RhoA activation resulting in cardiomyocyte hypertrophy associated with GATA4 stimulation
Liu et al., Cell Signal 2013 (Stomach Neoplasms) : PI3K/Akt dependent phosphorylation of GSK3ß and activation of RhoA regulate Wnt5a induced gastric cancer cell migration