Gene interactions and pathways from curated databases and text-mining

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NEUROD4 — RIT1

Text-mined interactions from Literome

Spencer et al., J Biol Chem 2002 (Pheochromocytoma) : In this study, we show that expression of constitutively active Rit ( RitL79 ) in PC6 cells results in neuronal differentiation , characterized by the elaboration of an extensive network of neurite-like processes that are morphologically distinct from those mediated by the expression of oncogenic Ras
Shi et al., Mol Cell Biol 2005 (MAP Kinase Signaling System) : Rit contributes to nerve growth factor induced neuronal differentiation via activation of B-Raf-extracellular signal regulated kinase and p38 mitogen activated protein kinase cascades ... Moreover, the ability of NGF to promote neuronal differentiation was attenuated by Rit knockdown
Andres et al., Methods Enzymol 2006 (MAP Kinase Signaling System...) : In this chapter, we discuss the reagents and methods used to characterize Rit mediated signaling to MAP kinase signaling pathways to determine the extracellular stimuli that regulate Rit activation and to characterize Rit induced neuronal differentiation
Rudolph et al., Biochim Biophys Acta 2007 (MAP Kinase Signaling System) : In this study, a series of Rit effector loop mutants was generated to test the importance of these cellular targets to Rit mediated neuronal differentiation