Gene interactions and pathways from curated databases and text-mining

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PIK3R1 — RLN2

Text-mined interactions from Literome

Nguyen et al., Mol Endocrinol 2003 : In addition, relaxin increased PI3K activity in THP-1 cells
Dessauer et al., Ann N Y Acad Sci 2005 : We have described a novel bifurcated pathway by which relaxin stimulates Gs alpha and PI3K/PKCzeta leading to increased cAMP production and increased VEGF gene expression
Ahmad et al., Mol Cell Endocrinol 2012 : Studies using chemical inhibitors and siRNAs to signaling molecules showed that PI3K , Akt, ERK and PKC-? and the transcription factors Elk-1, c-fos and, to a lesser extent, NF-?B are involved in relaxin 's induction of MMP-9