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MAPK11 — ROCK1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Pawlak et al., Mol Biol Cell 2002
(MAP Kinase Signaling System) :
Investigating the mechanism underlying this phenotypic reversion, we found that the sustained
MAPK signaling resulting from Ras-transformation
down-regulated the expression of
ROCKI and Rho-kinase, two-Rho effectors required for stress fiber formation, at the post-transcriptional level
Jia et al., Biol Cell 2006
:
The localized activation of an autocrine HGF/c-Met loop regulates
Rho/ROCK activation of p38
MAPK signalling to stimulate both membrane blebbing and pseudopod formation
Zeidan et al., Cardiovasc Res 2008
(Cardiomegaly) :
Leptin induced cardiomyocyte hypertrophy involves selective caveolae and
RhoA/ROCK dependent p38
MAPK translocation to nuclei
Lingor et al., Brain 2008
:
ROCK inhibition resulted in the activation of the intrinsic MAPK pathway, and the combination of CNTF and Y-27632
resulted in even more pronounced
MAPK activation
Zohrabian et al., Anticancer Res 2009
(Glioblastoma...) :
The cells were treated with Y-27632, a
ROCK inhibitor, and U0126, an upstream
MAPK kinase
inhibitor ( MEK ), alone or in combination with one another
Moey et al., J Pharmacol Exp Ther 2011
(Cardiomegaly) :
These results demonstrate a potent inhibitory effect of ginseng against leptin induced cardiac hypertrophy, an effect associated with prevention of
p115RhoGEF-RhoA/ROCK dependent p38
MAPK activation