Gene interactions and pathways from curated databases and text-mining

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PIK3R1 — RPL17

Text-mined interactions from Literome

Parry et al., Mol Cell Biol 2005 : Lastly, PD-1 ligation is more effective in suppressing CD3/CD28 induced changes in the T-cell transcriptional profile, suggesting that differential regulation of PI3K activation by PD-1 and CTLA-4 ligation results in distinct cellular phenotypes
Patsoukis et al., Cell cycle (Georgetown, Tex.) 2012 : The suppressive effect of PD-1 on Skp2 expression was mediated by inhibition of both PI3K/Akt and Ras/MEK/Erk pathways and was only partially reversed by IL-2, which restored activation of MEK/Erk but not Akt