Gene interactions and pathways from curated databases and text-mining

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PIK3R1 — RPS6KB1

Text-mined interactions from Literome

Tu et al., J Pharmacol Exp Ther 2002 : Inactivating PI3K with wortmannin prevented H2O2 from inducing Thr389 phosphorylation and p70S6K1 activation
Suh et al., J Biol Chem 2003 : The TSH induced S6K1 phosphorylation was inhibited by a dominant negative p85alpha regulatory subunit or by the PI3K inhibitors wortmannin and LY294002 ... These findings suggest an interaction between TSHR and PI3K , which is stimulated by TSH and cAMP and might involve the downstream S6K1 but not Akt/protein kinase B
Tang et al., Biochem J 2003 (Astrocytoma...) : This response was blocked by rapamycin, but was not markedly affected by 100 nM wortmannin, implying separate roles for mTOR and PI3K in S6K1 activation
Gao et al., Am J Physiol Cell Physiol 2004 (Ovarian Neoplasms) : The inhibition of PI3K activity also inhibited the phosphorylation of AKT and p70S6K1 , but not extracellular regulated kinase 1/2
Skinner et al., J Biol Chem 2004 (Ovarian Neoplasms) : The inhibition of PI3K by LY294002 inhibited p70S6K1 and HDM2 activity in the cells
Yang et al., Cell Microbiol 2006 (MAP Kinase Signaling System) : Furthermore, the inhibition of PI3K-Akt , but not ERK 1/2 pathway, attenuated M. tbc induced S6K1 phosphorylation, whereas PI3K inhibition enhanced p38 phosphorylation and apoptosis signal regulating kinase 1 activity during exposure to M. tbc