◀ Back to PIK3R1
PIK3R1 — RPS6KB1
Text-mined interactions from Literome
Tu et al., J Pharmacol Exp Ther 2002
:
Inactivating
PI3K with wortmannin
prevented H2O2 from inducing Thr389 phosphorylation and
p70S6K1 activation
Suh et al., J Biol Chem 2003
:
The TSH induced
S6K1 phosphorylation was
inhibited by a dominant negative p85alpha regulatory subunit or by the
PI3K inhibitors wortmannin and LY294002 ... These findings suggest an interaction between TSHR and
PI3K , which is stimulated by TSH and cAMP and might
involve the downstream
S6K1 but not Akt/protein kinase B
Tang et al., Biochem J 2003
(Astrocytoma...) :
This response was blocked by rapamycin, but was not markedly affected by 100 nM wortmannin, implying separate
roles for mTOR and
PI3K in
S6K1 activation
Gao et al., Am J Physiol Cell Physiol 2004
(Ovarian Neoplasms) :
The inhibition of
PI3K activity also
inhibited the phosphorylation of AKT and
p70S6K1 , but not extracellular regulated kinase 1/2
Skinner et al., J Biol Chem 2004
(Ovarian Neoplasms) :
The inhibition of
PI3K by LY294002
inhibited p70S6K1 and HDM2 activity in the cells
Yang et al., Cell Microbiol 2006
(MAP Kinase Signaling System) :
Furthermore, the inhibition of
PI3K-Akt , but not ERK 1/2 pathway, attenuated M. tbc
induced S6K1 phosphorylation, whereas PI3K inhibition enhanced p38 phosphorylation and apoptosis signal regulating kinase 1 activity during exposure to M. tbc