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RSPO3 — WNT16

Text-mined interactions from Literome

Kazanskaya et al., Dev Cell 2004 : R-Spondin2 is a secreted activator of Wnt/beta-catenin signaling and is required for Xenopus myogenesis
Binnerts et al., Proc Natl Acad Sci U S A 2007 : R-Spondin1 regulates Wnt signaling by inhibiting internalization of LRP6
Ohkawara et al., Dev Cell 2011 : Rspo3 binds syndecan 4 and induces Wnt/PCP signaling via clathrin mediated endocytosis to promote morphogenesis ... Here, we show that Rspo3 binds syndecan 4 (Sdc4) and that together they activate Wnt/PCP signaling
Hao et al., Nature 2012 (Colorectal Neoplasms...) : These data suggest that R-spondin enhances Wnt signalling by inhibiting ZNRF3
Jin et al., Int J Biochem Cell Biol 2012 (Bone Diseases...) : Recent advances in the RSPO research field revealed some of the in vivo functions of RSPOs and provided new information regarding the mechanistic roles of RSPO activity in regulation of WNT signaling