Gene interactions and pathways from curated databases and text-mining

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PIK3R1 — RUNX2

Text-mined interactions from Literome

Qiao et al., J Biol Chem 2004 : The phosphatidylinositol 3-kinase (PI3K) inhibitor, LY294002, reduced both basal and IGF-1 stimulated RUNX2 DNA binding activity in the absence of changes in RUNX2 protein as did the overexpression of the phosphatidylinositol 3-phosphate phosphatase, confirming that PI3K signaling mediates RUNX2 activation
Li et al., American journal of physiology. Renal physiology 2006 : Inhibition of PI3K with either wortmannin or LY-294002 significantly increased channel activity in the CCD from rats on a K-deficient ( KD ) diet or on a normal-K diet
Liu et al., Biochem Biophys Res Commun 2013 : Furthermore, in the presence of exogenous BMP-2, PI3K and Akt inhibitors blocked Runx2 and osteocalcin expression, although BMP-2 did not activate Akt