Gene interactions and pathways from curated databases and text-mining

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RUNX2 — TNFSF11

Text-mined interactions from Literome

O'Brien et al., Bone 2002 : Cbfa1 does not regulate RANKL gene activity in stromal/osteoblastic cells ... A striking decrease in the number of osteoclasts in Cbfa1-deficient mice suggested that Cbfa1 might be involved in RANKL expression ... Although these results can not rule out a novel function for Cbfa1 in RANKL expression, they demonstrate that Cbfa1 does not regulate RANKL gene activity in the same manner as known targets of this transcription factor, such as osteocalcin
Notoya et al., Biochem Biophys Res Commun 2004 : Runx-2 is not essential for the vitamin D-regulated expression of RANKL and osteoprotegerin in osteoblastic cells ... Thus, our findings indicate that Runx-2 is not essential for the expression of RANKL and OPG, and the formation of osteoclast-like cells
Usui et al., J Bone Miner Res 2008 (Fractures, Bone) : A reporter assay was used to determine whether BMP2 induced RANKL production is through transcriptional regulation of the RANKL promoter and whether it is mediated by Runx2
Galli et al., J Biol Chem 2009 : Consistent with this, neither Runx2 , nor Cbfb, a binding partner essential for Runx activity, are required for basal or PTH stimulated RANKL expression in fibroblastic stromal cell models