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RUNX2 — TNFSF11
Text-mined interactions from Literome
O'Brien et al., Bone 2002
:
Cbfa1 does not
regulate RANKL gene activity in stromal/osteoblastic cells ... A striking decrease in the number of osteoclasts in Cbfa1-deficient mice suggested that
Cbfa1 might be
involved in
RANKL expression ... Although these results can not rule out a novel function for Cbfa1 in RANKL expression, they demonstrate that
Cbfa1 does not
regulate RANKL gene activity in the same manner as known targets of this transcription factor, such as osteocalcin
Notoya et al., Biochem Biophys Res Commun 2004
:
Runx-2 is not
essential for the vitamin D-regulated expression of
RANKL and osteoprotegerin in osteoblastic cells ... Thus, our findings indicate that
Runx-2 is not
essential for the expression of
RANKL and OPG, and the formation of osteoclast-like cells
Usui et al., J Bone Miner Res 2008
(Fractures, Bone) :
A reporter assay was used to determine whether BMP2 induced
RANKL production is through transcriptional regulation of the RANKL promoter and whether it is
mediated by
Runx2
Galli et al., J Biol Chem 2009
:
Consistent with this, neither
Runx2 , nor Cbfb, a binding partner essential for Runx activity, are
required for basal or PTH stimulated
RANKL expression in fibroblastic stromal cell models