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RUNX3 — S100A8
Text-mined interactions from Literome
Tsang et al., Oncogene 2010
(Helicobacter Infections...) :
In this study, we show that H. pylori infection inactivates the gastric tumor suppressor
RUNX3 in a
CagA dependent manner
Liu et al., J Cell Biochem 2012
(MAP Kinase Signaling System) :
Helicobacter pylori
CagA inhibits the expression of
Runx3 via Src/MEK/ERK and p38 MAPK pathways in gastric epithelial cell ... Luciferase reporter assay was used to determine the
effects of
CagA on the 1,150 bp promoter activity of
Runx3 ... Signal inhibitors were used to detect the signal pathway ( s ) through which
CagA affects
Runx3 ... Our results showed that
CagA can
reduce the expression level of
Runx3 at both mRNA and protein levels significantly