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RAC2 — S1PR1

Text-mined interactions from Literome

Takuwa et al., Biochim Biophys Acta 2002 : Consistent with this, Edg1 and Edg3, and Edg5 regulate the activity of the Rho family GTPase Rac positively and negatively, respectively
Takuwa et al., American journal of cancer research 2011 : S1PR1 and S1PR3 mediate directed cell migration toward S1P through coupling to G ( i ) and activating Rac , a Rho family small G protein essential for cell migration ... In sharp contrast, S1PR2 mediates S1P inhibition of Rac at the site downstream of G ( 12/13 ) -mediated Rho activation, thus identified as the first G protein coupled receptor that negatively regulates Rac and cell migration