Gene interactions and pathways from curated databases and text-mining

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SAP30 — SIN3A

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Bocheński et al., J Physiol Pharmacol 1999 : Pretreatment with a PAF receptor antagonist ; WEB 2170 ( 5 and 25 mg/kg ) inhibited both PAP and SAP responses to LPS ( 4 mg/kg/min ) while an inhibitor of thromboxane synthesis ; Camonagrel ( 10 and 20 mg/kg ) abolished PAP response without a major effect on SAP response to LPS
Chacon-Cruz et al., Pediatr Res 2000 : PS+SAP also inhibited the formyl peptide induced [ Ca2+ ] response of neutrophils ( p < 0.01 ), but only in the presence of external Ca2+
Paul et al., J Biol Chem 2000 (MAP Kinase Signaling System) : Acute phorbol 12-myristate 13-acetate pretreatment also inhibited TNFalpha stimulated SAP kinase activity, while chronic pretreatment reversed the effects of UTP
Ochrietor et al., Cytokine 2000 : Role of STAT3 and C/EBP in cytokine dependent expression of the mouse serum amyloid P-component (SAP) and C-reactive protein (CRP) genes ... Role of STAT3 and C/EBP in cytokine dependent expression of the mouse serum amyloid P-component (SAP) and C-reactive protein (CRP) genes
de Haas et al., Infect Immun 2000 : Using HDL coated magnetic beads prebound with SAP, we demonstrated that HDL bound SAP prevented the binding of LPS to HDL
Hutchinson et al., Mol Med 2000 : Gel filtration chromatography and density gradient ultracentrifugation were used to compare SAP with the closely related molecule, C-reactive protein ( CRP ; which is known to be a single pentamer ) and the effect of human serum albumin on SAP autoaggregation was investigated
Lechner et al., J Biol Chem 2000 : Thus, Sds3p plays important roles in the integrity and catalytic activity of the Rpd3p.Sin3p complex
Singh et al., Scand J Immunol 2001 (Acute-Phase Reaction) : Both in vivo and in vitro the maximum production of CSFs occurred 6 h after initiation of stimulation, and returned to the background levels by 48 h. Mannose 6-P, mannose 1-P and mannose, and not other sugars inhibited the SAP induced production of CSFs by macrophages which suggests that SAP interaction with macrophages was mediated by specific glycoprotein-receptors ... A neutralizing ( 100 % ) concentration of rabbit antimouse interleukin (IL)-1 polyclonal antibody had no effect on the SAP induced CSF production, indicating that it would be IL-1 independent
Howie et al., Blood 2002 : Molecular dissection of the signaling and costimulatory functions of CD150 ( SLAM ) : CD150/SAP binding and CD150 mediated costimulation
Aoukaty et al., J Biol Chem 2002 (Lymphoproliferative Disorders) : We report here a role for phosphoinositide 3-kinase (PI3K) in the recruitment and association of SAP/SH2D1A to 2B4 in human NK cells
Chazova et al., Ter Arkh 2002 (Hypertension) : With sufficient antihypertensive effect on SAP , the drug did not induce an excessive decrease of DAP and did not affect heart rate and blood biochemistry
Mignot et al., Mol Microbiol 2002 : More importantly, Sap is required for the temporal control of eag, and EA1 is involved in strict feedback regulation of eag
Li et al., J Biol Chem 2003 (Lymphoproliferative Disorders) : Because SAP also blocked the recruitment of SHP-2 to SLAM in these cells, we propose a dual functional role for SAP in SLAM signaling by acting both as an adaptor for FynT and an inhibitor to SHP-2 binding
Bozzo et al., Eur J Biochem 2002 : SAP1 and SAP2 were activated by up to 80 % by 5 mm Mg2+ , and demonstrated potent competitive inhibition by molybdate, but mixed and competitive inhibition by Pi, respectively
Ding et al., World J Gastroenterol 2003 (Acute Disease...) : To establish a non-traumatic, easy to induce and reproducible mouse model of severe acute pancreatitis (SAP) induced with caerulein and lipopolyasccharide (LPS)
Shimizu et al., Nucleic Acids Res 2003 : We suggest that TBP binding is inhibited through chromatin modification by the Sin3p-Rpd3p and Isw2p complexes recruited by Ume6p
Aquilina et al., Biochem J 2003 : In the presence of physiological levels of Ca2+ , SAP was observed to exist primarily as a pentamer, reflecting its in vivo state
Kataoka et al., Cancer Res 2003 (Carcinoma, Hepatocellular...) : ING1b and ING2 also repressed the AFP promoter in Hep3B p53-null cell lines, and p53 coexpression enhanced this transcriptional repression
Boston et al., Experimental biology and medicine (Maywood, N.J.) 2004 : We hypothesize that PS+SAP suppresses neutrophil activation by depletion of internal Ca ( ++ ) stores and that PS+SAP induces depletion through release of Ca ( ++ ) stores and through inhibition of Ca ( ++ ) influx
Valdez et al., J Biol Chem 2004 (Autoimmune Diseases...) : Cross linking of NTB-A also induces phosphorylation of NTB-A and the association of SAP ( SLAM associated protein ), the protein absent in X-linked lymphoproliferative disease
Vulin et al., J Biol Chem 2004 : Finally, JNK/SAPK activity was found to increase in response to oxidants, and inhibition of JNK/SAP blocked TBHQ increased PAI-1-luciferase expression
Simarro et al., Int Immunol 2004 : SAP increases FynT kinase activity and is required for phosphorylation of SLAM and Ly9 ... SAP increases FynT kinase activity and is required for phosphorylation of SLAM and Ly9 ... Here we demonstrate that SAP is required for phosphorylation of both SLAM and Ly9 in thymocytes and peripheral T cells ... Here we demonstrate that SAP is required for phosphorylation of both SLAM and Ly9 in thymocytes and peripheral T cells
Taylor et al., Infect Immun 2005 (Candidiasis, Vulvovaginal) : SAP5 expression was induced soon after infection, whereas SAP4 was expressed at later times and in fewer cells compared with SAP5
Veerhuis et al., Neurobiol Dis 2005 : Also, SAP and C1q enhanced PrP-peptide fibril formation as revealed by electron microscopy and thioflavin S-based quantitative assays
Wang et al., J Immunol 2005 : However, mycobacterial infection or TLR2 stimulation up-regulated expression of mammalian Sin3A , a corepressor that is required for MHC class II repression by HDAC
Chuang et al., Blood 2005 (Lymphohistiocytosis, Hemophagocytic) : Interestingly, EBV LMP1 could transcriptionally inhibit the expression of SAP/SH2D1A and activate downstream molecules ERK and interferon-gamma (IFN-gamma)
Zhang et al., Nucleic Acids Res 2005 : The ErbB3 binding protein Ebp1 interacts with Sin3A to repress E2F1 and AR-mediated transcription ... Functionally, Sin3A enhanced the ability of Ebp1 to repress transcription of androgen receptor (AR) and E2F1 regulated genes ... Functionally, Sin3A enhanced the ability of Ebp1 to repress transcription of androgen receptor (AR) and E2F1 regulated genes
Armstrong et al., J Infect Dis 2006 (Disease Models, Animal...) : Here, we show that serum amyloid P component (SAP), a normal human plasma protein, specifically protects mice against the lethal toxicity of Stx2, both when injected into wild-type mice and when expressed transgenically ; in the presence of human SAP , there was greatly reduced in vivo localization of Stx2 to the kidneys, suggesting a possible mechanism of protection
Macdonald et al., Scand J Immunol 2006 : The SAP-monocyte interaction was calcium independent and readily inhibited by C1q
Kammanadiminti et al., J Biol Chem 2006 (Colitis) : Overexpression of wild type Hsp27 amplified the effects of SAP, whereas a phosphorylation-deficient mutant of Hsp27 abrogated SAP induced NF-kappaB inhibition
Chen et al., Mol Cell Biol 2006 : SAP promotes SLAM family receptor induced protein tyrosine phosphorylation, due to its capacity to recruit the Src related kinase FynT
Mantovani et al., Vascul Pharmacol 2006 (Cardiovascular Diseases...) : CRP and SAP are produced primarily in the liver in response to IL-6 , while PTX3 is produced by a variety of tissues and cells and in particular by innate immunity cells in response to proinflammatory signals and Toll-like receptor ( TLR ) engagement
Yasuda et al., Pancreas 2006 (Bacterial Infections...) : These results suggest that HMGB1 may act as a key mediator for inflammation and organ failure in SAP
Mauceri et al., J Neurochem 2007 : On the contrary, SAP97-Ser232 phosphorylation occurs within the postsynaptic compartment and is responsible for both the disruption of NR2A/SAP97 complex and, consequently, for NR2A insertion in the postsynaptic membrane ... On the contrary, SAP97-Ser232 phosphorylation occurs within the postsynaptic compartment and is responsible for both the disruption of NR2A/SAP97 complex and, consequently, for NR2A insertion in the postsynaptic membrane
Endt et al., Eur J Immunol 2007 : IL-2 stimulation leads to an up-regulation of SAP expression, which can be enhanced by IL-12 , the stimulation of TLR3 by polyinosinic-polycytidylic acid ( poly ( I:C ) ) and to a lesser extent by IFN-alpha ... IL-2 stimulation leads to an up-regulation of SAP expression, which can be enhanced by IL-12, the stimulation of TLR3 by polyinosinic-polycytidylic acid ( poly ( I:C ) ) and to a lesser extent by IFN-alpha
McCausland et al., J Immunol 2007 : SAP regulation of follicular helper CD4 T cell development and humoral immunity is independent of SLAM and Fyn kinase
Kammanadiminti et al., Infect Immun 2007 : Moreover, inhibiting the classical pathway of NF-kappaB activation did not affect SAP induced MCP-1 expression ... Instead, we find that SAP induced MCP-1 expression is dependent on posttranslational modification of the NFkappaB p65 subunit
Villar et al., Infect Immun 2007 (Candidiasis, Oral) : Mucosal tissue invasion by Candida albicans is associated with E-cadherin degradation, mediated by transcription factor Rim101p and protease Sap5p
Nakajima et al., Pancreas 2007 (Acute Disease...) : Apoptosis of ileal mucosa was accelerated in SAP , and VEGF significantly reduced the apoptosis ... Microvessel counts were significantly reduced in SAP , and VEGF significantly increased them
Veis et al., Mol Cell Biol 2007 : Since the removal of Sin3 is independent of Ndd1 recruitment and Cdc28/Clb activity it represents a unique regulatory step which is distinct from transcriptional activation
Pisalyaput et al., J Neurochem 2008 : Interestingly, SAP did not induce caspase and calpain activation, suggesting that C1q neuroprotection is in distinct from caspase and calpain pathways ... Interestingly, SAP did not induce caspase and calpain activation, suggesting that C1q neuroprotection is in distinct from caspase and calpain pathways
Li et al., Immunity 2007 : Furthermore, SAP was critical for IL-4 production by T-CD4 T cells, but the PKCtheta deficiency did not alter the ability of T-CD4 T cells to produce cytokines
el-Kashef et al., Pulm Pharmacol 1991 : Atropine or secoverine ( SEC ) inhibited equally the PVR and SAP responses to ACh
Zhang et al., Cancer Lett 2008 (Carcinoma, Hepatocellular...) : Researches have shown that ING2 can activate p53 and p53 mediated apoptotic pathway involved in the hepatocarcinogenesis
Furukawa et al., Jpn J Pharmacol 1991 : Before atropine, topical application of hexamethonium at the locus for stimulation of intracardiac parasympathetic nerves to the SA ( SAP stimulation ) or AV nodal region ( AVP stimulation ) abolished almost totally negative chronotropic responses to SAP and cervical vagus stimulation or negative dromotropic responses to AVP and cervical vagus stimulation, respectively
Haudek et al., Proc Natl Acad Sci U S A 2008 (Cardiomyopathies...) : However, unlike wild-type mice, SAP in FcRgamma ( -/- ) mice failed to inhibit the development of fibrosis and cardiac dysfunction and did not diminish the numbers of alpha-smooth muscle actin ( + ) and CD34 ( + ), CD45 ( + ) fibroblasts that were typical for I/RC
Li et al., Cell Signal 2008 (Lymphoproliferative Disorders) : Expression of SAP in the A20 B cell line led to a marked reduction in Blnk phosphorylation, a decrease in Akt activation, and a near-complete ablation of phosphorylation of the MAP kinases Erk1/2, p38 and JNK upon colligation of FcgammaRIIB with the B cell receptor (BCR) ... Expression of SAP in the A20 B cell line led to a marked reduction in Blnk phosphorylation, a decrease in Akt activation, and a near-complete ablation of phosphorylation of the MAP kinases Erk1/2, p38 and JNK upon colligation of FcgammaRIIB with the B cell receptor (BCR)
Li et al., Cell Signal 2009 (Lymphoproliferative Disorders) : Depletion of SAP by siRNA caused a significant decrease in NCK1 tyrosine phosphorylation as well as the phosphorylation of other T cell receptor ( TCR ) downstream proteins such as LAT and SLP-76
Farhana et al., Mol Cancer Ther 2009 : SHP and Sin3A expression are essential for adamantyl substituted retinoid related molecule mediated nuclear factor-kappaB activation, c-Fos/c-Jun expression, and cellular apoptosis ... SHP and Sin3A expression are essential for adamantyl substituted retinoid related molecule mediated nuclear factor-kappaB activation, c-Fos/c-Jun expression, and cellular apoptosis ... We examined the effect of loss of SHP and Sin3A expression in a number of cell types on 3-Cl-AHPC mediated growth inhibition and apoptosis induction, 3-Cl-AHPC mediated nuclear factor-kappaB (NF-kappaB) activation, and 3-Cl-AHPC mediated increase in c-Fos and c-Jun expression ... We examined the effect of loss of SHP and Sin3A expression in a number of cell types on 3-Cl-AHPC mediated growth inhibition and apoptosis induction, 3-Cl-AHPC mediated nuclear factor-kappaB (NF-kappaB) activation, and 3-Cl-AHPC mediated increase in c-Fos and c-Jun expression ... We examined the effect of loss of SHP and Sin3A expression in a number of cell types on 3-Cl-AHPC mediated growth inhibition and apoptosis induction, 3-Cl-AHPC mediated nuclear factor-kappaB (NF-kappaB) activation, and 3-Cl-AHPC mediated increase in c-Fos and c-Jun expression
Ellison-Zelski et al., Mol Cell Biol 2009 : Reduction of Sin3A expression by RNA interference specifically inhibits estrogen induced repression of ESR1
Kamei et al., Journal of hepato-biliary-pancreatic sciences 2010 (Acute Disease...) : TREM-1 may act as an important mediator for inflammation and organ injury in SAP
Pilling et al., PloS one 2009 : In addition, IL-4, IL-12, IL-13, IFN-gamma, and SAP differentially regulate the expression of CD32, CD163 , CD172a, and CD206 on both macrophages and fibrocytes ... In addition, IL-4, IL-12, IL-13, IFN-gamma, and SAP differentially regulate the expression of CD32 , CD163, CD172a, and CD206 on both macrophages and fibrocytes ... In addition, IL-4, IL-12, IL-13, IFN-gamma, and SAP differentially regulate the expression of CD32, CD163, CD172a, and CD206 on both macrophages and fibrocytes ... In addition, IL-4, IL-12, IL-13, IFN-gamma, and SAP differentially regulate the expression of CD32, CD163, CD172a , and CD206 on both macrophages and fibrocytes
Enose-Akahata et al., PLoS Pathog 2009 (Paraparesis, Tropical Spastic) : High expression of CD244 and SAP regulated CD8 T cell responses of patients with HTLV-I associated neurologic disease
Smith et al., Chem Biol 2010 : Loss of ING2 disrupts the in vivo binding of the Sin3 complex to the p21 promoter, an important target gene for cell growth inhibition by SAHA
Zhou et al., Hepatobiliary Pancreat Dis Int 2010 (Acute Disease...) : We assessed the effects of the inhibitor of MCP-1 , Bindarit, on SAP and explored the mechanisms underlying SAP
Dovey et al., Proc Natl Acad Sci U S A 2010 : Deletion of HDAC1, but not HDAC2 , causes a significant reduction in the HDAC activity of Sin3A , NuRD, and CoREST corepressor complexes
Yusuf et al., J Immunol 2010 : These data illustrate complexities of SAP dependent SLAM family receptor signaling, revealing a prominent role for SLAM receptor ligation in IL-4 production by GC CD4 T cells but not in T ( FH ) cell and GC T ( FH ) cell differentiation
Verykokakis et al., Immunity 2010 : Here we showed that Id3 ( -/- ) CD8 ( + ) T cells had an innate-like phenotype and required SAP for their development
Pietrella et al., Infect Immun 2010 (Inflammation) : In particular Sap1, Sap2 , and Sap6 significantly induced interleukin-1ß (IL-1ß) , tumor necrosis factor alpha ( TNF-a ), and IL-6 production ... In particular Sap1, Sap2 , and Sap6 significantly induced interleukin-1ß (IL-1ß), tumor necrosis factor alpha ( TNF-a ), and IL-6 production
Mulder et al., J Alzheimers Dis 2010 (Alzheimer Disease) : In conclusion, these data suggest that local production of SAP and CRP in the AD brain does not substantially contribute to the CSF levels
Garlanda et al., Curr Pharm Des 2011 (Atherosclerosis...) : CRP and SAP are produced primarily in the liver in response to IL-6 , while PTX3 is produced by a variety of tissues and cells and in particular by innate immunity cells in response to proinflammatory signals and Toll-like receptor ( TLR ) engagement
Ramakrishna et al., J Biol Chem 2011 (Neoplasms) : SDS3 is a key component of the histone deacetylase (HDAC) dependent Sin3A co-repressor complex, serving to maintain its HDAC activity
Schwalbe et al., J Biol Chem 1990 : Furthermore, SAP had little or no effect on the ability of C4BP to bind C4b
Mulder et al., Exp Neurol 2012 (Alzheimer Disease) : Further, SAP-C1q increased SCARB1 expression in control astrocytes when combined with Aßoligo
Dang et al., Gastroenterology research and practice 2012 : Severe acute pancreatitis (SAP) can cause intestinal barrier dysfunction ( IBD ) , which significantly increases the disease severity and risk of mortality
Shi et al., Biochem J 2012 : We demonstrated that the transcriptional repression of Foxk1 is dependent on the Sin3-Sds3 repression complex, and knockdown of Sds3 results in cell-cycle arrest
Vitoriano-Souza et al., PloS one 2012 : With regard to cytokines, the SAP led to production of interleukin (IL)-2 , IL-6, and IL-4 ... With regard to cytokines, the SAP led to production of interleukin (IL)-2, IL-6, and IL-4 ... With regard to cytokines, the SAP led to production of interleukin (IL)-2, IL-6 , and IL-4
Yang et al., Cancer Biol Ther 2012 (Glioblastoma) : In addition, siRNA silencing of Sin3B induced an increase in the expression of c-Myc and Sin3A, which contributed to increased expression of Mad4 ... The association of c-IAP1 with Sin3B or Mad4 suggested that Sin3B might interfere with the binding of c-IAP1 to Mad4 ; however, overexpression of Sin3B did not affect the interaction between Mad4 and c-IAP1 ... Exogenous expression of Sin3B also inhibited c-IAP1 mediated degradation of Mad1, TRAF2 , c-IAP2 and ASK1, known targets of c-IAP1 E3 ligase activity ... Exogenous expression of Sin3B also inhibited c-IAP1 mediated degradation of Mad1, TRAF2, c-IAP2 and ASK1 , known targets of c-IAP1 E3 ligase activity ... Exogenous expression of Sin3B also inhibited c-IAP1 mediated degradation of Mad1, TRAF2, c-IAP2 and ASK1, known targets of c-IAP1 E3 ligase activity
Backues et al., Autophagy 2012 : The Ume6-Sin3-Rpd3 complex regulates ATG8 transcription to control autophagosome size
Schmidt et al., Diabetes Technol Ther 2012 (Diabetes Mellitus, Type 1) : Conclusions : This study documents persisting beneficial effects of SAP on HbA1c , treatment satisfaction, magnitude of diabetes related problems, and fear of hypoglycemia 36 months after therapy start
Madapura et al., Cell cycle (Georgetown, Tex.) 2012 : Modifying p53 levels using Nutlin-3, which specifically dissociates the MDM2-p53 interaction, was sufficient to upregulate SAP expression, indicating that SAP is a target of p53 in T cells
Yang et al., Zhongguo Zhong Xi Yi Jie He Za Zhi 2013 (Disease Models, Animal...) : To observe the effects of Qingyi Granule ( QYG ) on the changes of total protein expressions in the pancreatic tissue of rats with severe acute pancreatitis (SAP) induced by sodium taurocholate (STC)
Lin et al., Inflammation 1990 : Purified mouse interferon-beta (IFN-beta) , but not IFN-alpha, also induced SAP production
Nogee et al., Am J Perinatol 1988 (Hyaline Membrane Disease...) : SAP-35 expression is enhanced by 3'-5'-cyclic adenosine monophosphate and epidermal growth factor during perinatal differentiation of type II epithelial cells
Siripont et al., Cell Immunol 1988 : Binding of SAP to M phi required Ca2+ or Mg2+ and was inhibited at a pH less than or equal to 5.6 ... Binding of SAP to M phi required Ca2+ or Mg2+ and was inhibited at a pH less than or equal to 5.6
Ozkan et al., J Trauma 1987 : Reversal of SAP induced immunosuppression and SAP detection by a monoclonal antibody
Sarlo et al., Cell Immunol 1985 : The mouse macrophage line P388D1, also could bind SAP and display enhanced IL-1 production in response to SAP
Korewicki et al., Cor Vasa 1985 (Coronary Disease...) : The effects of intravenous nitroglycerin ( NTG ), trimetaphan ( TMP ), and phentolamine (PTL) on pulmonary artery diastolic pressure ( PADP ), systemic arterial pressure (SAP) , cardiac index ( CI ) and systemic vascular resistance ( SVR ) in patients ( 12 in each treated group ) with chronic ischaemic heart failure are analyzed
Sipe et al., Ann N Y Acad Sci 1982 (Acute Disease...) : Unlike SAA synthesis, BCG-preinfection fails to synergistically augment the LPS induced SAP response
Bugni et al., Am Heart J 1980 (Arterial Occlusive Diseases...) : The effect of mean systemic arterial pressure (SAP) on myocardial O2 consumption ( MVO2 ) coronary blood flow (CBF) and the reduction of left ventricular ( LV ) reserve capacity resulting from coronary artery occlusion was studied in 25 open-chest pentobarbital anesthetized dogs with fixed cardiac output and controlled heart rate ( HR ) and SAP
Büscher et al., Mol Cell Biol 1995 : Both CSF-1 and LPS rapidly activate the MAPK network and induce the phosphorylation of two distinct ternary complex factors ( TCFs ), TCF/Elk and TCF/SAP ... Both CSF-1 and LPS rapidly activate the MAPK network and induce the phosphorylation of two distinct ternary complex factors ( TCFs ), TCF/Elk and TCF/SAP
Nawaz et al., Mol Gen Genet 1994 : The yeast SIN3 gene product negatively regulates the activity of the human progesterone receptor and positively regulates the activities of GAL4 and the HAP1 activator ... The yeast SIN3 gene product negatively regulates the activity of the human progesterone receptor and positively regulates the activities of GAL4 and the HAP1 activator ... The yeast SIN3 gene product negatively regulates the activity of the human progesterone receptor and positively regulates the activities of GAL4 and the HAP1 activator ... SIN3 positively regulates the transcriptional activities of GAL4 and the HAP1 activator ... SIN3 positively regulates the transcriptional activities of GAL4 and the HAP1 activator ... Deletion analysis of the SIN3 PAH motifs shows that the PAH3 motif is essential for SIN3 mediated regulation of hPR, GAL4, and the HAP1 activator ... Deletion analysis of the SIN3 PAH motifs shows that the PAH3 motif is essential for SIN3 mediated regulation of hPR, GAL4 , and the HAP1 activator
García de Frutos et al., J Immunol 1994 : Even though C4BP, C4 ( H2O ), and SAP form a multimolecular complex in fluid phase, SAP was found to inhibit binding of C4BP to immobilized C4 ( H2O ) ... Heparin, which is known to inhibit the interaction between SAP and C4BP, was also found to counteract the inhibitory effect of SAP on C4BP binding to C4 ( H2O )
Ku et al., Cytokine 1993 (Carcinoma, Hepatocellular...) : By contrast, gene expression of the major APR of the mouse, serum amyloid P-component (SAP) , a structural homologue of CRP, increased in response to either IL-1 or IL-6 under the same conditions ... By contrast, gene expression of the major APR of the mouse, serum amyloid P-component (SAP) , a structural homologue of CRP, increased in response to either IL-1 or IL-6 under the same conditions
Husøy et al., Carcinogenesis 1993 (Cell Transformation, Neoplastic) : The effects of 12-O-tetradecanoylphorbol-13-acetate ( TPA ), 12-deoxyphorbol-13-phenylacetate ( DOPP ), 12-deoxyphorbol-13-phenylacetate-20-acetate ( DOPP A ), sapintoxin D (SAP D) and sapintoxin A (SAP A) on the decrease in [ 125I ] epidermal growth factor (EGF) binding ( indicating protein kinase C activation ), suppression of gap junctional intercellular communication ( GJIC ) and induction of morphological cell transformation (MCT) in Syrian hamster embryo (SHE) cells were investigated
Tsai et al., J Biol Chem 1993 : Binding of ARF1 and -3, but not ARF5, was enhanced by SAP ... Binding of ARF1 and -3, but not ARF5 , was enhanced by SAP ... B36, an inactive derivative of BFA, did not inhibit SAP dependent binding of ARF1 and -3
Molewijk et al., Psychopharmacologia 1995 : The 5-HT2C/1B receptor agonist m-CPP , the inverse BZD receptor agonists FG 7142 and DMCM, and the alpha 2-adrenoceptor antagonist yohimbine, to all of which putative anxiogenic effects have been ascribed, had no effect on SAP directed towards the prod
Zahedi et al., J Biol Chem 1996 : Binding of SAP to type IV collagen was inhibited by both SAP and C-reactive protein (CRP)
Zahedi et al., J Biol Chem 1997 : Competition binding assays indicate that the binding of SAP to laminin is inhibited by both SAP and its analog, C-reactive protein, as well as phosphatidylethanolamine ... Competition binding assays indicate that the binding of SAP to laminin is inhibited by both SAP and its analog, C-reactive protein, as well as phosphatidylethanolamine
Whitmarsh et al., Mol Cell Biol 1997 : In contrast, SAP-1 is activated by ERK and p38 MAP kinases but not by JNK
de Haas et al., J Immunol 1998 : In search for the LPS binding site of SAP, we found that pep27-39 , a 13-mer peptide consisting of amino acids 27-39 of SAP, competitively inhibited the binding of LPS to SAP ... Performing gel filtration of FITC labeled ReLPS incubated with soluble CD14, we showed that SAP could not prevent binding of LPS to soluble CD14 , in contrast to pep27-39 ... Performing gel filtration of FITC labeled ReLPS incubated with soluble CD14, we showed that SAP could not prevent binding of LPS to soluble CD14, in contrast to pep27-39
Liedtke et al., Oncogene 1998 (Cell Transformation, Neoplastic) : Regulation of Bcr-Abl induced SAP kinase activity and transformation by the SHPTP1 protein tyrosine phosphatase ... Regulation of Bcr-Abl induced SAP kinase activity and transformation by the SHPTP1 protein tyrosine phosphatase