Gene interactions and pathways from curated databases and text-mining

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SCG5 — TNF

Text-mined interactions from Literome

Harada et al., J Interferon Cytokine Res 2004 : The addition of recombinant murine GM-CSF ( rMuGM-CSF ) to spleen cell cultures from various strains of mice synergistically enhanced IFN-gamma, TNF-alpha and IL-12p70 in the presence of SCG
Harada et al., J Interferon Cytokine Res 2006 : We recently found that the splenocytes from naive DBA/1 and DBA/2 mice are potently induced by SCG to produce interferon- gamma (IFN-gamma), tumor necrosis factor-alpha (TNF-alpha) , granulocyte-macrophage colony stimulating factor ( GM-CSF ), and interleukin-12p70 (IL-12p70), and that GM-CSF plays a key biologic role among these cytokines ... Cell-cell contact involving intercellular adhesion molecule-1 ( ICAM-1 ) and lymphocyte function associated antigen-1 ( LFA-1 ) was an essential step for the induction of GM-CSF and IFN-gamma by SCG but not for the induction of TNF-alpha or IL-12p70 by SCG ... SCG directly induced adherent splenocytes to produce TNF-alpha and IL-12p70 ... GM-CSF was required for the induction of TNF-alpha by SCG , and in turn, TNF-alpha enhanced the release of GM-CSF and thereby augmented the induction of IL-12p70 and IFN-gamma by SCG
Harada et al., Microbiol Immunol 2006 (Leukopenia) : The levels of interferon-(IFN-)gamma, tumor necrosis factor-(TNF-)alpha , granulocyte-macrophage-colony stimulating factor ( GM-CSF ), interleukin-(IL-) 6 and IL-12p70 were significantly increased by SCG in CY-treated mice ... Neutralizing GM-CSF significantly inhibited the induction of IFN-gamma, TNF-alpha and IL-12p70 by SCG ... Blocking dectin-1 significantly inhibited the induction of TNF-alpha and IL-12p70 production by SCG
Harada et al., J Interferon Cytokine Res 2008 : Blocking dectin-1 significantly inhibited the induction of TNF-alpha production by SCG
Hida et al., Inflamm Res 2009 : The effect of SCG on TNF-alpha production was partially inhibited by CRDO
Bissonnette et al., Int Arch Allergy Immunol 1995 : However, SCG , NED, and IFN inhibit TNF-alpha dependent cytotoxicity by both PMCs and IMMCs and reduce the steady-state levels of mRNA for TNF-alpha in PMCs ... The inhibitory effect of SCG and NED on TNF-alpha release from MCs may explain some of their anti-inflammatory and therapeutic effects