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EGF — SERPINE1

Text-mined interactions from Literome

Park et al., Biol Reprod 1999 : In the presence of EGF , however, some activity of tPA-PAI was detected at 12 h of culture
Takahashi et al., Neuroreport 2000 : Neither epidermal growth factor (EGF) , basic fibroblast growth factor (bFGF), phorbol myristate acetate ( PMA ) nor forskolin increased PAI-1 mRNA expression in PC12 cells
Kotlarz et al., Biochem Biophys Res Commun 2002 : EGF , phorbol esters or TGF-beta1 predominantly increased PAI-1 protein expression in TSH treated cells
Guan et al., Gynecol Obstet Invest 2003 (Endometriosis) : EGF increased the release of PAI-1 from stromal cells from women without endometriosis ( p < 0.05 ) but decreased the release of PAI-1 from stromal cells from endometriotic women ( p < 0.05 )
Samarakoon et al., J Cell Physiol 2005 (MAP Kinase Signaling System) : AG1478 suppressed ( in a dose dependent fashion ) EGF induced PAI-1 protein levels and, at a final concentration of 2.5 muM, virtually eliminated EGF dependent PAI-1 synthesis
Paugh et al., FASEB J 2008 (Glioblastoma) : Moreover, EGF enhances PAI-1 expression in glioma cells ... Although multiple known signaling cascades are activated by EGF in glioma cells, we show for the first time that EGF enhances expression of PAI-1 via sequential activation of c-Src, protein kinase C delta (PKCdelta), and sphingosine kinase 1 (SphK1), the enzyme that produces sphingosine-1-phosphate ... Down-regulation of PKCdelta abolished EGF induced SphK1 translocation and up-regulation of PAI-1 by EGF ; whereas, down-regulation of PKCalpha had no effect on the EGF induced PAI-1 activation but enhanced its basal expression ... Similarly, inhibition of c-Src activity by PP2 blocked both EGF induced translocation of SphK1 and PKCdelta to the plasma membrane and up-regulation of PAI-1 expression ... Furthermore, SphK1 was indispensable for both EGF induced c-Jun phosphorylation and PAI-1 expression
Alberti et al., Oncogene 2012 (Neoplasms, Glandular and Epithelial...) : A significant reduction of EGF stimulated IL-6/PAI-1 secretion was also obtained with the NFkB inhibitor dehydroxymethylepoxyquinomicin
Song et al., J Biol Chem 2012 (MAP Kinase Signaling System) : EGF and TGFß regulate PAI-1 by synergistically activating transcription, which is further amplified by a decrease in the rate of mRNA degradation, the latter being regulated only by EGF
Piquette et al., J Clin Endocrinol Metab 1993 : We also studied the effects of hCG and EGF on PAI-1 and PAI-2 mRNA levels in cultured GLC ; GLC were cultured in serum-free medium for various times within 24 h with or without hCG and for 6 h with or without hCG, EGF, or EGF plus hCG ... PAI-1 mRNA levels were not affected by hCG or EGF at 6 h of culture, but PAI-2 mRNA levels were significantly increased by EGF at 6 h of culture