Gene interactions and pathways from curated databases and text-mining

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PIK3R1 — SERPINE1

Text-mined interactions from Literome

Venugopal et al., Proc Natl Acad Sci U S A 2004 (Insulin Resistance) : Insulin induced PAI-1 gene expression is up-regulated by a specific inhibitor of PI3K
Mukai et al., Am J Physiol Heart Circ Physiol 2007 : The increase in PAI-1 was due to transcriptional and posttranscriptional mechanisms as PI3K inhibitors increased PAI-1 promoter activity and mRNA stability
Hsieh et al., J Rheumatol 2007 (Osteoarthritis, Knee) : Enzyme linked immunosorbent assay and gelatin zymography were used to investigate the effects of ERK 1/2 inhibitor U0126, JNK and p38 inhibitor SB203580, and PI3K inhibitor LY294002 on the secretion of u-PA, PAI-1 , MMP-2, and MMP-9 in early osteoarthritic tissue cultures, with or without interleukin 1alpha (IL-1alpha) and lipopolysaccharide (LPS) induction
Jerczynska et al., Regul Pept 2009 : Similarly, CNP and the inhibitors of ERK1/2 ( PD098059 ) and PI3K ( LY294002 ) attenuated PAI-1 expression induced by TNFalpha