◀ Back to PIK3R1
PIK3R1 — SERPINE1
Text-mined interactions from Literome
Venugopal et al., Proc Natl Acad Sci U S A 2004
(Insulin Resistance) :
Insulin induced
PAI-1 gene expression is
up-regulated by a specific inhibitor of
PI3K
Mukai et al., Am J Physiol Heart Circ Physiol 2007
:
The increase in PAI-1 was due to transcriptional and posttranscriptional mechanisms as
PI3K inhibitors
increased PAI-1 promoter activity and mRNA stability
Hsieh et al., J Rheumatol 2007
(Osteoarthritis, Knee) :
Enzyme linked immunosorbent assay and gelatin zymography were used to investigate the
effects of ERK 1/2 inhibitor U0126, JNK and p38 inhibitor SB203580, and
PI3K inhibitor LY294002 on the secretion of u-PA,
PAI-1 , MMP-2, and MMP-9 in early osteoarthritic tissue cultures, with or without interleukin 1alpha (IL-1alpha) and lipopolysaccharide (LPS) induction
Jerczynska et al., Regul Pept 2009
:
Similarly, CNP and the inhibitors of ERK1/2 ( PD098059 ) and
PI3K ( LY294002 )
attenuated PAI-1 expression induced by TNFalpha