Gene interactions and pathways from curated databases and text-mining

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PIK3R1 — SETD2

Text-mined interactions from Literome

Tomita et al., Biochem J 2007 (Leukemia, T-Cell) : The PI3K inhibitor LY294002 suppressed HIF-1alpha protein expression, HIF-1 DNA binding and HIF-1 transcriptional activity in HTLV-1 infected T-cell lines ... The results of the present study suggest that PI3K/Akt activation induced by Tax leads to activation of HIF-1
Jiang et al., Adv Cancer Res 2009 (Neoplasms...) : PI3K signaling regulates tumor growth and angiogenesis by activating AKT and other targets, and by inducing HIF-1 and VEGF expression
Kim et al., Eur J Immunol 2010 (Airway Remodeling...) : Moreover, we found that inhibition of the PI3K p110d isoform (PI3K-d) or HIF-1a reduced OVA induced HIF-1a activation in airway epithelial cells
Suzuki et al., Mol Med Report 2008 : In addition, our study revealed that neither the PI3K/Akt nor the p53 signaling pathway is required for Zeb induced HIF-1a degradation
Chern et al., Planta Med 2011 (Cerebral Infarction...) : Our results indicate that andrographolide reduces NOX2 and iNOS expression possibly by impairing PI3K/AKT dependent NF- ?B and HIF-1 a activation
Du et al., PloS one 2011 (Breast Neoplasms) : Both PI3K inhibitor LY294002 and ERK inhibitor U0126 suppressed hypoxia induced Rac1 activation as well as HIF-1a expression
Iqbal et al., Molecular cancer 2013 (Neoplasms) : We observed that insulin up-regulated PKM2 expression, through PI3K/mTOR mediated HIF1a induction, but significantly reduced PKM2 activity independent of this pathway