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PIK3R1 — SETD2
Text-mined interactions from Literome
Tomita et al., Biochem J 2007
(Leukemia, T-Cell) :
The
PI3K inhibitor LY294002
suppressed HIF-1alpha protein expression,
HIF-1 DNA binding and HIF-1 transcriptional activity in HTLV-1 infected T-cell lines ... The results of the present study suggest that
PI3K/Akt activation induced by Tax
leads to activation of
HIF-1
Jiang et al., Adv Cancer Res 2009
(Neoplasms...) :
PI3K signaling
regulates tumor growth and angiogenesis by activating AKT and other targets, and by inducing
HIF-1 and VEGF expression
Kim et al., Eur J Immunol 2010
(Airway Remodeling...) :
Moreover, we found that inhibition of the
PI3K p110d isoform (PI3K-d) or HIF-1a
reduced OVA induced
HIF-1a activation in airway epithelial cells
Suzuki et al., Mol Med Report 2008
:
In addition, our study revealed that neither the
PI3K/Akt nor the p53 signaling pathway is
required for Zeb induced
HIF-1a degradation
Chern et al., Planta Med 2011
(Cerebral Infarction...) :
Our results indicate that andrographolide reduces NOX2 and iNOS expression possibly by impairing
PI3K/AKT dependent NF- ?B and
HIF-1 a activation
Du et al., PloS one 2011
(Breast Neoplasms) :
Both
PI3K inhibitor LY294002 and ERK inhibitor U0126
suppressed hypoxia induced Rac1 activation as well as
HIF-1a expression
Iqbal et al., Molecular cancer 2013
(Neoplasms) :
We observed that insulin up-regulated PKM2 expression, through
PI3K/mTOR mediated
HIF1a induction, but significantly reduced PKM2 activity independent of this pathway