Gene interactions and pathways from curated databases and text-mining

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AKT1 — SH2B2

Pathways - manually collected, often from reviews:

  • WikiPathways Insulin Signaling: GSK3B/AKT2/AKT1/SGK3/SGK1/GSK3A/PDPK1/SGK2 → STXBP2/CYTH3/KIF5B/EHD2/ARF6/RAB4A/CAP1/STXBP1/CRK/STXBP4/TBC1D4/SH2B2/EHD1/ARHGAP33/STX4/SNAP25/RHOQ/SNAP23/CBLB/STXBP3/CBL/FLOT2/CBLC/MYO1C/RHOJ/SORBS1/ARF1/RAPGEF1/VAMP2/FLOT1/KIF3A (activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Wang et al., J Biol Chem 2004 : To gain insight into the mechanism by which the adapter protein SH2-B promotes nerve growth factor (NGF) mediated neuronal differentiation and survival, the effect of SH2-B on the serine/threonine kinase Akt/protein kinase B and downstream effector proteins was examined ... To gain insight into the mechanism by which the adapter protein SH2-B promotes nerve growth factor (NGF) mediated neuronal differentiation and survival, the effect of SH2-B on the serine/threonine kinase Akt/protein kinase B and downstream effector proteins was examined
Yoshiga et al., Mol Endocrinol 2007 : Insulin induced Akt activation and the phosphorylation of forkhead transcription factor ( FKHR/Foxo1 ), a negative regulator of PPARgamma transcription, were up-regulated by SH2-B overexpression, but reduced in SH2-B-deficient MEFs