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AKT1 — SH2B2
Pathways - manually collected, often from reviews:
-
WikiPathways Insulin Signaling:
GSK3B/AKT2/AKT1/SGK3/SGK1/GSK3A/PDPK1/SGK2
→
STXBP2/CYTH3/KIF5B/EHD2/ARF6/RAB4A/CAP1/STXBP1/CRK/STXBP4/TBC1D4/SH2B2/EHD1/ARHGAP33/STX4/SNAP25/RHOQ/SNAP23/CBLB/STXBP3/CBL/FLOT2/CBLC/MYO1C/RHOJ/SORBS1/ARF1/RAPGEF1/VAMP2/FLOT1/KIF3A
(activation)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Wang et al., J Biol Chem 2004
:
To gain insight into the mechanism by which the adapter protein SH2-B promotes nerve growth factor (NGF) mediated neuronal differentiation and survival, the
effect of
SH2-B on the serine/threonine kinase
Akt/protein kinase B and downstream effector proteins was examined ... To gain insight into the mechanism by which the adapter protein SH2-B promotes nerve growth factor (NGF) mediated neuronal differentiation and survival, the
effect of
SH2-B on the serine/threonine kinase
Akt/protein kinase B and downstream effector proteins was examined
Yoshiga et al., Mol Endocrinol 2007
:
Insulin induced
Akt activation and the phosphorylation of forkhead transcription factor ( FKHR/Foxo1 ), a negative regulator of PPARgamma transcription, were
up-regulated by
SH2-B overexpression, but reduced in SH2-B-deficient MEFs