Gene interactions and pathways from curated databases and text-mining

◀ Back to PIK3R1

PIK3R1 — SHC1

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Ramshaw et al., Blood 2007 : These results reveal a previously unrecognized negative signaling role for Tyr577 in beta ( c ) and demonstrate that uncoupling Shc from cytokine receptors enhances PI3K signaling as well as survival and proliferation
Radhakrishnan et al., J Biol Chem 2008 (MAP Kinase Signaling System) : In contrast to MAPK activation the role of Shc in modulating PI3K in response to IGF-I has not been determined
Lee et al., J Biol Chem 2010 : OSS induced activation of PI3K/Akt/mTOR/p70S6K and cell proliferation were inhibited by specific antibodies or small interference RNAs of alpha ( v ) beta ( 3 ) and beta ( 1 ) integrins and by dominant negative mutants of Shc ( Shc-SH2 ) and focal adhesion kinase ( FAK ) ( FAK ( F397Y ) )