Rawadi et al., J Bone Miner Res 2003
:
In contrast, blocking Wnt/LRP5 signaling or protein synthesis inhibited the ability of both BMP-2 and Shh to induce ALP in mesenchymal cells ... Our data strongly suggest that the capacity of BMP-2 and Shh to induce ALP relies on Wnt expression and the Wnt/LRP5 signaling cascade
Han et al., Shanghai Kou Qiang Yi Xue 2009
:
N-Shh also promoted ALP activities ( P < 0.05 ) and bone matrix calcification