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SHH — WNT16

Text-mined interactions from Literome

Treichel et al., Genes Dev 2003 : We present evidence that mBtd is required during early limb development to maintain, but not to initiate Wnt/beta-catenin dependent FGF, Shh , and BMP mediated signaling
Robertson et al., Dev Dyn 2004 : We demonstrate that activation of Wnt signaling results in an inhibition of the Shh response in neural tissue
Lei et al., Dev Cell 2006 : Here, we show that Wnt pathway inhibitors regulate the threshold response of a ventral Shh target gene, Nkx2.2, to establish its restricted expression in the ventral spinal cord
Iwatsuki et al., Proc Natl Acad Sci U S A 2007 : Exogenously added Shh suppressed expression of endogenous Shh and inhibited Wnt/beta-catenin signaling ( assessed in TOPGAL mice ), further implicating Shh as an inhibitor of the Wnt/beta-catenin pathway
Martinez-Ferre et al., J Neurosci 2013 : Here we investigated a key role of Wnt signaling in the molecular regulation of ZLI positioning and Shh expression, using experimental embryology in ovo in the chick