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IL1A — SIGIRR
Text-mined interactions from Literome
Huang et al., J Immunol 2006
(Keratitis...) :
SIGIRR also negatively
regulated IL-1 and LPS, but not poly ( I:C ) -mediated signaling and NF-kappaB activation ... These data provide evidence that
SIGIRR is critical in resistance to P. aeruginosa corneal infection by down regulating type 1 immunity, and that it negatively
regulates IL-1 and TLR4 signaling
Sham et al., PLoS Pathog 2013
:
One reason for the innate hypo-responsiveness of IEC is their expression of Single Ig IL-1 Related Receptor
(SIGIRR) , a negative
regulator of
interleukin (IL)-1 and TLR signaling