Gene interactions and pathways from curated databases and text-mining

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IL1A — SIGIRR

Text-mined interactions from Literome

Huang et al., J Immunol 2006 (Keratitis...) : SIGIRR also negatively regulated IL-1 and LPS, but not poly ( I:C ) -mediated signaling and NF-kappaB activation ... These data provide evidence that SIGIRR is critical in resistance to P. aeruginosa corneal infection by down regulating type 1 immunity, and that it negatively regulates IL-1 and TLR4 signaling
Sham et al., PLoS Pathog 2013 : One reason for the innate hypo-responsiveness of IEC is their expression of Single Ig IL-1 Related Receptor (SIGIRR) , a negative regulator of interleukin (IL)-1 and TLR signaling