Gene interactions and pathways from curated databases and text-mining

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PIK3R1 — SKP2

Text-mined interactions from Literome

Hsieh et al., Br J Pharmacol 2012 : Prodigiosin also down-regulated E2F1 ( mediates PI3K/PKB induced SKP2 transcription ), but E2F1 overexpression failed to restore SKP2 expression in prodigiosin treated cells
Patsoukis et al., Cell cycle (Georgetown, Tex.) 2012 : The suppressive effect of PD-1 on Skp2 expression was mediated by inhibition of both PI3K/Akt and Ras/MEK/Erk pathways and was only partially reversed by IL-2, which restored activation of MEK/Erk but not Akt