Gene interactions and pathways from curated databases and text-mining

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PIK3R1 — SLC22A3

Text-mined interactions from Literome

Yan et al., Biochem Biophys Res Commun 2009 (Carcinoma, Hepatocellular...) : Hypoxia induced EMT was blocked by PI3K inhibitor LY294002
Zuo et al., Breast Cancer Res 2010 (Breast Neoplasms...) : To define the potential inter-mediate steps between mPRalpha and PI3K, we demonstrated that mPRalpha, caveolin-1 (Cav-1), and epidermal growth factor receptor (EGFR) are colocalized in the membrane of caveolar vesicle and the P4-repressed EMT in MB468 cells can be blocked by EGFR inhibitor ( AG1478 ) and PI3K inhibitor ( wortmannin )
Ho et al., Mol Cancer Res 2012 (Carcinoma, Renal Cell...) : Inhibition of PI3K/AKT by LY294002 reactivated GSK-3ß and suppressed the TNF-a induced EMT of RCC cells
Han et al., PloS one 2012 (Breast Neoplasms...) : The inhibitors of PI3K-AKT and ERK1/2 pathways, LY294002 and U0126, both significantly suppressed EMT and CSC phenotype, indicating that AKT and ERK1/2 pathways are required for miR-21 mediating EMT and CSC phenotype