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PIK3R1 — SLC22A3
Text-mined interactions from Literome
Yan et al., Biochem Biophys Res Commun 2009
(Carcinoma, Hepatocellular...) :
Hypoxia induced
EMT was
blocked by
PI3K inhibitor LY294002
Zuo et al., Breast Cancer Res 2010
(Breast Neoplasms...) :
To define the potential inter-mediate steps between mPRalpha and PI3K, we demonstrated that mPRalpha, caveolin-1 (Cav-1), and epidermal growth factor receptor (EGFR) are colocalized in the membrane of caveolar vesicle and the P4-repressed
EMT in MB468 cells can be
blocked by EGFR inhibitor ( AG1478 ) and
PI3K inhibitor ( wortmannin )
Ho et al., Mol Cancer Res 2012
(Carcinoma, Renal Cell...) :
Inhibition of
PI3K/AKT by LY294002 reactivated GSK-3ß and
suppressed the TNF-a induced
EMT of RCC cells
Han et al., PloS one 2012
(Breast Neoplasms...) :
The inhibitors of
PI3K-AKT and ERK1/2 pathways, LY294002 and U0126, both significantly
suppressed EMT and CSC phenotype, indicating that AKT and ERK1/2 pathways are required for miR-21 mediating EMT and CSC phenotype