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PIK3R1 — SLC25A16
Text-mined interactions from Literome
Junttila et al., Cancer Cell 2009
(Breast Neoplasms) :
Ligand independent
HER2/HER3/PI3K complex is disrupted by trastuzumab and is effectively
inhibited by the PI3K inhibitor
GDC-0941
Yao et al., Clin Cancer Res 2009
(Breast Neoplasms) :
We therefore investigated the combinatorial activity of
GDC-0941 , a novel class I
PI3K inhibitor , with standard-of-care therapies for HER2 amplified breast cancer
Wallin et al., Sci Transl Med 2010
(Breast Neoplasms...) :
We used preclinical cancer models to determine the effects of combining the DNA damaging drug doxorubicin with
GDC-0941 , a class I
PI3K inhibitor that is currently being tested in early-stage clinical trials
Yuan et al., Oncogene 2013
(Adenocarcinoma...) :
Further, we used this model to test the efficacy of
GDC-0941 , a
PI3K inhibitor , in clinical development, and showed that the tumors respond to PI3K inhibition
Wallin et al., Clin Cancer Res 2012
(Breast Neoplasms...) :
GDC-0941 , a novel class I selective
PI3K inhibitor , enhances the efficacy of docetaxel in human breast cancer models by increasing cell death in vitro and in vivo ... The current study was intended to determine whether
GDC-0941 , an orally bioavailable class I selective
PI3K inhibitor , enhances the antitumor activity of docetaxel in human breast cancer models in vitro and in vivo
Lin et al., Int J Cancer 2013
(Brain Neoplasms...) :
Palomid 529 lacked affinity for these transporters in vitro, in contrast to
GDC-0941 , a small molecule
PI3K inhibitor , which we used as control substance for in vitro transport
Sampath et al., Neoplasia (New York, N.Y.) 2013
:
GDC-0980 , a dual
PI3K/mTOR inhibitor , was found to reduce micro-CT angiography vascular density, while VSI MRI demonstrated a significant reduction in vessel density and an increase in mean vessel size, consistent with a loss of small functional vessels and a substantial antivascular response