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PIK3R1 — SLC2A4
Pathways - manually collected, often from reviews:
-
KEGG Type II diabetes mellitus:
PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3/PIK3R5
→
SLC2A4
(protein-protein, indirect effect)
Text-mined interactions from Literome
Shang et al., J Endocrinol 2008
:
Rb(1) induced glucose uptake as well as GLUT1 and
GLUT4 translocations was
inhibited by the
PI3K inhibitor
Stuart et al., J Clin Endocrinol Metab 2009
:
L6 myoblasts in culture also expressed and translocated GLUT12 in response to insulin, but inhibiting
PI3-K prevented the translocation of GLUT12 and
GLUT4
Xu et al., Eur Rev Med Pharmacol Sci 2011
(Diabetes Mellitus, Experimental) :
Effect of insulin in combination with selenium on blood glucose and
PI3K mediated
GLUT4 expression in skeletal muscle of streptozotocin induced diabetic rats
Xu et al., Eur Rev Med Pharmacol Sci 2011
(Diabetes Mellitus, Experimental) :
Effect of insulin in combination with selenium on
Irs/PI3K mediated
GLUT4 expression in cardiac muscle of diabetic rats
Ji et al., PloS one 2013
:
Moreover, the
PI3K inhibitor wortmannin significantly
inhibited activation of Akt and AMPK, reduced
GLUT4 translocation, glucose uptake and ultimately, depressed IPC induced cardioprotection
Quon et al., Biochem Biophys Res Commun 1996
:
Our data suggest that overexpression of PDGF-R mediates positive effects on
GLUT4 translocation by a wortmannin sensitive pathway not
dependent on direct interaction of the PDGF-R with
PI3K