Shah et al., Am J Physiol Heart Circ Physiol 2010
:
These results suggest that 1 ) ANG- ( 1-7 ) increased ANP secretion at high atrial pacing via the Mas/PI3K/Akt pathway and the activation of Na(+)/H(+) exchanger-1 and CaMKII and 2 ) ANG- ( 1-7 ) decreased cardiac hypertrophy which might be mediated by ANP
Jenkins et al., Dev Biol 2012
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Here we report that mammary branching morphogenesis induced by transforming growth factor-alpha ( TGFa ) requires PI3K dependent NHE1-activation and subsequent pHi alkalization