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FGF8 — SMAD1

Text-mined interactions from Literome

Miyoshi et al., Mol Cell Endocrinol 2010 : Interestingly, FGF-8 enhanced BMP induced Smad1/5/8 and Id-1-promoter activities with decreased expression of Smad6/7 ... Since the SAPK/JNK inhibitor inhibited FGF-8 effects in upregulating Id-1 transcription, SAPK/JNK appears to be involved in the mechanism by which FGF-8 enhances BMP-Smad signaling
Stuhlmiller et al., Development 2012 : Our results identify an early requirement for FGF/MAPK signaling in amniote neural crest induction and suggest an intriguing role for FGF mediated Smad inhibition in ectodermal development