Gene interactions and pathways from curated databases and text-mining

◀ Back to PIK3R1

PIK3R1 — SMAD1

Text-mined interactions from Literome

Qiao et al., Cancer Lett 2006 (Neuroblastoma) : GRP induced activation of PI3-K , resulting in neuroblastoma cell growth promotion, is potentiated by down-regulation of TGF-beta/Smad signaling
Graham et al., Prostate 2009 (Neoplasm Metastasis...) : PI3K/Akt dependent transcriptional regulation and activation of BMP-2-Smad signaling by NF-kappaB in metastatic prostate cancer cells
Heger et al., J Cell Physiol 2010 (Cardiomegaly...) : Specific inhibitors of PI3K ( 10 microM LY290042 or 10 nM wortmannin ) or ERK ( 10 microM PD98059 ) also blocked GDF15 induced hypertrophy and SMAD activation
Ueki et al., Glia 2013 : Interestingly, BMP/Smad1/5/8 activation downstream of PI3K/AKT signaling was also necessary for robust Müller glial proliferation, though activation of BMP/Smad1/5/8 signaling alone failed to stimulate their proliferation