Gene interactions and pathways from curated databases and text-mining

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PIK3R1 — SMAD4

Text-mined interactions from Literome

Qiao et al., Cancer Lett 2006 (Neuroblastoma) : GRP induced activation of PI3-K , resulting in neuroblastoma cell growth promotion, is potentiated by down-regulation of TGF-beta/Smad signaling
Graham et al., Prostate 2009 (Neoplasm Metastasis...) : PI3K/Akt dependent transcriptional regulation and activation of BMP-2-Smad signaling by NF-kappaB in metastatic prostate cancer cells
Choi et al., Photochem Photobiol 2009 : The TE mRNA increase required activation of Smad4 , shown using Smad4 siRNA, and also involved the ERK1/2, p38 and JNK MAP kinases but not PI3K
Heger et al., J Cell Physiol 2010 (Cardiomegaly...) : Specific inhibitors of PI3K ( 10 microM LY290042 or 10 nM wortmannin ) or ERK ( 10 microM PD98059 ) also blocked GDF15 induced hypertrophy and SMAD activation