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MAPK12 — SMAD7
Text-mined interactions from Literome
Wrana et al., Science's STKE : signal transduction knowledge environment 2000
:
In the cytosol,
Smad translocation might be
inhibited by
mitogen activated protein kinase dependent phosphorylation, whereas in the nucleus Smads interact with a number of transcription factors that themselves are primary targets of other signaling pathways
Akel et al., Platelets 2007
(Leukemia, Erythroblastic, Acute...) :
Stable over-expression of
Smad7 in K562 cells ( K562/7 )
prevented activation of Smad2/3 and
MAPK ( ERK1/2, p38 and JNK1/2 ) proteins by activin-A/TGF-beta1 and subsequent induction of erythroid differentiation
Zhao et al., Mol Cell Biochem 2008
(Fibrosis...) :
Additionally, the inhibition of
MAPK signaling
had no effect on
Smad activation elicited by chymase
Shukla et al., Am J Respir Cell Mol Biol 2009
(MAP Kinase Signaling System...) :
HGF induced expression of
Smad7 , an inhibitor of TGF-beta signaling, in a
mitogen activated protein kinase dependent manner
Zhu et al., Prostate 2010
(MAP Kinase Signaling System) :
These findings suggest a dual role for PHB as a downstream determinant of the cellular response to TGF-beta via
Smad dependent pathway ( apoptosis ) and
MAPK intracellular signaling ( survival )
Rodrigues Díez et al., PloS one 2010
(Fibrosis) :
In cultured rat VSMCs, direct
AngII/Smad pathway activation was
mediated by p38
MAPK and ROCK activation
Ungefroren et al., Int J Oncol 2011
(Carcinoma, Pancreatic Ductal...) :
Biochemically, dnSrc inhibition failed to block TGF-ß1/ALK5 induced activation of Smad2 and Smad3, but partially
inhibited transcriptional activation of
TGF-ß/Smad-responsive reporter genes, and effectively blocked basal and TGF-ß1 induced activation of p38
MAPK