Gene interactions and pathways from curated databases and text-mining

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ATM — SMC3

Pathways - manually collected, often from reviews:

  • NCI Pathway Database ATM pathway: MRN complex/ATM/MDC1/H2AX/RNF8/53BP1/BRCA1 complex (MRE11A-NBN-RAD50-ATM-H2AFX-MDC1-RNF8-TP53BP1-BRCA1) → SMC3 (SMC3) (modification, activates) Luo et al., J Biol Chem 2008
    Evidence: mutant phenotype, assay, physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *