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GNB2L1 — SMPD2
Pathways - manually collected, often from reviews:
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/FAN/NSMASE complex (TNFRSF1A-NSMAF-SMPD2-TNF)
→
RACK1 (GNB2L1)
(modification, collaborate)
Tcherkasowa et al., J Immunol 2002
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/FAN/NSMASE complex (TNFRSF1A-NSMAF-SMPD2-TNF)
→
sTNF-alpha/TNFR1A/FAN/NSMASE/RACK1 complex (TNFRSF1A-NSMAF-SMPD2-GNB2L1-TNF)
(modification, collaborate)
Tcherkasowa et al., J Immunol 2002
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
RACK1 (GNB2L1)
→
sTNF-alpha/TNFR1A/FAN/NSMASE/RACK1 complex (TNFRSF1A-NSMAF-SMPD2-GNB2L1-TNF)
(modification, collaborate)
Tcherkasowa et al., J Immunol 2002
Evidence: mutant phenotype, assay, physical interaction
Text-mined interactions from Literome
Tcherkasowa et al., J Immunol 2002
:
Furthermore, activation of
N-SMase by TNF was strongly
enhanced when
RACK1 , FAN, and a noncytotoxic TNF-R55 mutant were expressed concurrently, suggesting RACK1 as a modulator of N-SMase activation
Möhlig et al., Exp Cell Res 2007
:
Our results demonstrate that activation of PKC is not required for
regulation of
N-SMase by
FAN/RACK1