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SMAD7 — SMURF1

Pathways - manually collected, often from reviews:

• KEGG TGF-beta signaling pathway: SMAD6/SMAD7 → SMURF1/SMURF2 (protein-protein, binding/association)
• NCI Pathway Database TGF-beta receptor signaling: SMAD7/SMURF1-2 complex (SMAD7-SMURF1_SMURF2) → TGFB/TGFBR2/TGFBR1/PML/SARA/SMAD2-3/AP2B2 complex (TGFBR1-PML-ZFYVE9-SMAD2_SMAD3-TGFBR2) (modification, collaborate)
  Wu et al., Science 2000, Yao et al., J Biol Chem 2000, Kavsak et al., Mol Cell 2000, Ebisawa et al., J Biol Chem 2001, Huse et al., Mol Cell 2001, Lu et al., J Biol Chem 2002, Suzuki et al., J Biol Chem 2002, Hayes et al., J Cell Biol 2002, Yao et al., Mol Biol Cell 2002, Di Guglielmo et al., Nat Cell Biol 2003, Lin et al., Nature 2004, Hayashi et al., Cell 1997, Nakao et al., Nature 1997, Abdollah et al., J Biol Chem 1997, Lo et al., EMBO J 1998, Chen et al., Genes Dev 1998, Tsukazaki et al., Cell 1998
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database TGF-beta receptor signaling: SMAD7/SMURF1-2 complex (SMAD7-SMURF1_SMURF2) → TGFB/TGFBR2/TGFBR1 complex (TGFBR1-TGFBR2) (modification, collaborate)
  Wu et al., Science 2000, Yao et al., J Biol Chem 2000, Kavsak et al., Mol Cell 2000, Ebisawa et al., J Biol Chem 2001, Huse et al., Mol Cell 2001, Lu et al., J Biol Chem 2002, Suzuki et al., J Biol Chem 2002, Hayes et al., J Cell Biol 2002, Yao et al., Mol Biol Cell 2002, Di Guglielmo et al., Nat Cell Biol 2003, Lin et al., Nature 2004, Hayashi et al., Cell 1997, Nakao et al., Nature 1997, Abdollah et al., J Biol Chem 1997, Lo et al., EMBO J 1998, Chen et al., Genes Dev 1998, Tsukazaki et al., Cell 1998
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database TGF-beta receptor signaling: SMAD7/SMURF1-2 complex (SMAD7-SMURF1_SMURF2) → Caveolin-1 (CAV1) (modification, collaborate) Wu et al., Science 2000, Yao et al., J Biol Chem 2000, Kavsak et al., Mol Cell 2000, Ebisawa et al., J Biol Chem 2001, Huse et al., Mol Cell 2001, Lu et al., J Biol Chem 2002, Suzuki et al., J Biol Chem 2002, Hayes et al., J Cell Biol 2002, Yao et al., Mol Biol Cell 2002, Di Guglielmo et al., Nat Cell Biol 2003, Lin et al., Nature 2004, Hayashi et al., Cell 1997, Nakao et al., Nature 1997, Abdollah et al., J Biol Chem 1997, Lo et al., EMBO J 1998, Chen et al., Genes Dev 1998, Tsukazaki et al., Cell 1998
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database TGF-beta receptor signaling: SMAD7/SMURF1-2 complex (SMAD7-SMURF1_SMURF2) → TGFB/TGFBR2/TGFBR1/SMAD7/SMURF1-2/CAV1 complex (TGFBR1-SMAD7-SMURF1_SMURF2-CAV1-TGFBR2) (modification, collaborate)
  Wu et al., Science 2000, Yao et al., J Biol Chem 2000, Kavsak et al., Mol Cell 2000, Ebisawa et al., J Biol Chem 2001, Huse et al., Mol Cell 2001, Lu et al., J Biol Chem 2002, Suzuki et al., J Biol Chem 2002, Hayes et al., J Cell Biol 2002, Yao et al., Mol Biol Cell 2002, Di Guglielmo et al., Nat Cell Biol 2003, Lin et al., Nature 2004, Hayashi et al., Cell 1997, Nakao et al., Nature 1997, Abdollah et al., J Biol Chem 1997, Lo et al., EMBO J 1998, Chen et al., Genes Dev 1998, Tsukazaki et al., Cell 1998
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database TGF-beta receptor signaling: SMAD7/SMURF1-2 complex (SMAD7-SMURF1_SMURF2) → PML/SARA/SMAD2-3 complex (ZFYVE9-SMAD2_SMAD3-PML) (modification, collaborate)
  Wu et al., Science 2000, Yao et al., J Biol Chem 2000, Kavsak et al., Mol Cell 2000, Ebisawa et al., J Biol Chem 2001, Huse et al., Mol Cell 2001, Lu et al., J Biol Chem 2002, Suzuki et al., J Biol Chem 2002, Hayes et al., J Cell Biol 2002, Yao et al., Mol Biol Cell 2002, Di Guglielmo et al., Nat Cell Biol 2003, Lin et al., Nature 2004, Hayashi et al., Cell 1997, Nakao et al., Nature 1997, Abdollah et al., J Biol Chem 1997, Lo et al., EMBO J 1998, Chen et al., Genes Dev 1998, Tsukazaki et al., Cell 1998
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database TGF-beta receptor signaling: SMAD7/SMURF1-2 complex (SMAD7-SMURF1_SMURF2) → FKBP12 (FKBP1A) (modification, collaborate) Wu et al., Science 2000, Yao et al., J Biol Chem 2000, Kavsak et al., Mol Cell 2000, Ebisawa et al., J Biol Chem 2001, Huse et al., Mol Cell 2001, Lu et al., J Biol Chem 2002, Suzuki et al., J Biol Chem 2002, Hayes et al., J Cell Biol 2002, Yao et al., Mol Biol Cell 2002, Di Guglielmo et al., Nat Cell Biol 2003, Lin et al., Nature 2004, Hayashi et al., Cell 1997, Nakao et al., Nature 1997, Abdollah et al., J Biol Chem 1997, Lo et al., EMBO J 1998, Chen et al., Genes Dev 1998, Tsukazaki et al., Cell 1998
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database TGF-beta receptor signaling: TGFB/TGFBR2/TGFBR1/PML/SARA/SMAD2-3/AP2B2 complex (TGFBR1-PML-ZFYVE9-SMAD2_SMAD3-TGFBR2) → TGFB/TGFBR2/TGFBR1/SMAD7/SMURF1-2/CAV1 complex (TGFBR1-SMAD7-SMURF1_SMURF2-CAV1-TGFBR2) (modification, collaborate)
  Wu et al., Science 2000, Yao et al., J Biol Chem 2000, Kavsak et al., Mol Cell 2000, Ebisawa et al., J Biol Chem 2001, Huse et al., Mol Cell 2001, Lu et al., J Biol Chem 2002, Suzuki et al., J Biol Chem 2002, Hayes et al., J Cell Biol 2002, Yao et al., Mol Biol Cell 2002, Di Guglielmo et al., Nat Cell Biol 2003, Lin et al., Nature 2004, Hayashi et al., Cell 1997, Nakao et al., Nature 1997, Abdollah et al., J Biol Chem 1997, Lo et al., EMBO J 1998, Chen et al., Genes Dev 1998, Tsukazaki et al., Cell 1998
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database TGF-beta receptor signaling: TGFB/TGFBR2/TGFBR1 complex (TGFBR1-TGFBR2) → TGFB/TGFBR2/TGFBR1/SMAD7/SMURF1-2/CAV1 complex (TGFBR1-SMAD7-SMURF1_SMURF2-CAV1-TGFBR2) (modification, collaborate)
  Wu et al., Science 2000, Yao et al., J Biol Chem 2000, Kavsak et al., Mol Cell 2000, Ebisawa et al., J Biol Chem 2001, Huse et al., Mol Cell 2001, Lu et al., J Biol Chem 2002, Suzuki et al., J Biol Chem 2002, Hayes et al., J Cell Biol 2002, Yao et al., Mol Biol Cell 2002, Di Guglielmo et al., Nat Cell Biol 2003, Lin et al., Nature 2004, Hayashi et al., Cell 1997, Nakao et al., Nature 1997, Abdollah et al., J Biol Chem 1997, Lo et al., EMBO J 1998, Chen et al., Genes Dev 1998, Tsukazaki et al., Cell 1998
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database TGF-beta receptor signaling: Caveolin-1 (CAV1) → TGFB/TGFBR2/TGFBR1/SMAD7/SMURF1-2/CAV1 complex (TGFBR1-SMAD7-SMURF1_SMURF2-CAV1-TGFBR2) (modification, collaborate)
  Wu et al., Science 2000, Yao et al., J Biol Chem 2000, Kavsak et al., Mol Cell 2000, Ebisawa et al., J Biol Chem 2001, Huse et al., Mol Cell 2001, Lu et al., J Biol Chem 2002, Suzuki et al., J Biol Chem 2002, Hayes et al., J Cell Biol 2002, Yao et al., Mol Biol Cell 2002, Di Guglielmo et al., Nat Cell Biol 2003, Lin et al., Nature 2004, Hayashi et al., Cell 1997, Nakao et al., Nature 1997, Abdollah et al., J Biol Chem 1997, Lo et al., EMBO J 1998, Chen et al., Genes Dev 1998, Tsukazaki et al., Cell 1998
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database TGF-beta receptor signaling: TGFB/TGFBR2/TGFBR1/SMAD7/SMURF1-2/CAV1 complex (TGFBR1-SMAD7-SMURF1_SMURF2-CAV1-TGFBR2) → PML/SARA/SMAD2-3 complex (ZFYVE9-SMAD2_SMAD3-PML) (modification, collaborate)
  Wu et al., Science 2000, Yao et al., J Biol Chem 2000, Kavsak et al., Mol Cell 2000, Ebisawa et al., J Biol Chem 2001, Huse et al., Mol Cell 2001, Lu et al., J Biol Chem 2002, Suzuki et al., J Biol Chem 2002, Hayes et al., J Cell Biol 2002, Yao et al., Mol Biol Cell 2002, Di Guglielmo et al., Nat Cell Biol 2003, Lin et al., Nature 2004, Hayashi et al., Cell 1997, Nakao et al., Nature 1997, Abdollah et al., J Biol Chem 1997, Lo et al., EMBO J 1998, Chen et al., Genes Dev 1998, Tsukazaki et al., Cell 1998
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: SMAD6-7/SMURF1/SMAD1 complex (SMAD6_SMAD7-SMURF1-SMAD1) → Gsk3beta (GSK3B) (proteasomal ubiquitin-dependent protein catabolic process, collaborate) Sapkota et al., Mol Cell 2007
• NCI Pathway Database BMP receptor signaling: SMAD7/SMURF1 complex (SMAD7-SMURF1) → SMAD1 (SMAD1) (modification, collaborate) Murakami et al., Mol Biol Cell 2003, Hoodless et al., Cell 1996, Kretzschmar et al., Genes Dev 1997, Imamura et al., Nature 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database BMP receptor signaling: SMAD7/SMURF1 complex (SMAD7-SMURF1) → BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) (modification, collaborate)
  Murakami et al., Mol Biol Cell 2003, Hoodless et al., Cell 1996, Kretzschmar et al., Genes Dev 1997, Imamura et al., Nature 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database BMP receptor signaling: SMAD7/SMURF1 complex (SMAD7-SMURF1) → BMP2-4/BMPR2/BMPR1A-1B/RGM/SMAD7/SMURF1 complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2-SMAD7-SMURF1) (modification, collaborate)
  Murakami et al., Mol Biol Cell 2003, Hoodless et al., Cell 1996, Kretzschmar et al., Genes Dev 1997, Imamura et al., Nature 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database BMP receptor signaling: SMAD1 (SMAD1) → BMP2-4/BMPR2/BMPR1A-1B/RGM/SMAD7/SMURF1 complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2-SMAD7-SMURF1) (modification, collaborate)
  Murakami et al., Mol Biol Cell 2003, Hoodless et al., Cell 1996, Kretzschmar et al., Genes Dev 1997, Imamura et al., Nature 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database BMP receptor signaling: BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) → BMP2-4/BMPR2/BMPR1A-1B/RGM/SMAD7/SMURF1 complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2-SMAD7-SMURF1) (modification, collaborate)
  Murakami et al., Mol Biol Cell 2003, Hoodless et al., Cell 1996, Kretzschmar et al., Genes Dev 1997, Imamura et al., Nature 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database BMP receptor signaling: SMAD6-7/SMURF1/SMAD1 complex (SMAD6_SMAD7-SMURF1-SMAD1) → NUP214 (NUP214) (translocation, inhibits) Sapkota et al., Mol Cell 2007, Hoodless et al., Cell 1996, Kretzschmar et al., Genes Dev 1997
  Evidence: mutant phenotype, assay
• NCI Pathway Database Signaling events mediated by HDAC Class I: SMURF1 (SMURF1) → HDAC1/Smad7 complex (HDAC1-SMAD7) (modification, activates)
  Ebisawa et al., J Biol Chem 2001, Grönroos et al., Mol Cell 2002*
  Evidence: assay, other species
• NCI Pathway Database BMP receptor signaling: SMAD6-7/SMURF1 complex (SMAD6_SMAD7-SMURF1) → SMAD1 (SMAD1) (modification, collaborate) Zhu et al., Nature 1999, Murakami et al., Mol Biol Cell 2003, Sapkota et al., Mol Cell 2007
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database BMP receptor signaling: SMAD6-7/SMURF1 complex (SMAD6_SMAD7-SMURF1) → SMAD6-7/SMURF1/SMAD1 complex (SMAD6_SMAD7-SMURF1-SMAD1) (modification, collaborate)
  Zhu et al., Nature 1999, Murakami et al., Mol Biol Cell 2003, Sapkota et al., Mol Cell 2007
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database BMP receptor signaling: SMAD1 (SMAD1) → SMAD6-7/SMURF1/SMAD1 complex (SMAD6_SMAD7-SMURF1-SMAD1) (modification, collaborate)
  Zhu et al., Nature 1999, Murakami et al., Mol Biol Cell 2003, Sapkota et al., Mol Cell 2007
  Evidence: mutant phenotype, physical interaction
• Reactome Reaction: SMAD7 → SMURF1 (reaction) Kavsak et al., Mol Cell 2000, Ebisawa et al., J Biol Chem 2001, Suzuki et al., J Biol Chem 2002, Tajima et al., J Biol Chem 2003, Kuratomi et al., Biochem J 2005, Chong et al., Proc Natl Acad Sci U S A 2010*
• Reactome Reaction: SMAD7 → SMURF1 (direct_complex) Ebisawa et al., J Biol Chem 2001, Tajima et al., J Biol Chem 2003, Chong et al., Proc Natl Acad Sci U S A 2010*

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind_translation Interaction: SMAD7 — SMURF1 (two hybrid) Yamashita et al., Cell 2005*
• IRef Bind_translation Interaction: SMAD7 — SMURF1 (coimmunoprecipitation) Barrios-Rodiles et al., Science 2005
• IRef Biogrid Interaction: SMAD7 — SMURF1 (physical association, affinity chromatography technology) Fei et al., Mol Cell Biol 2013*
• IRef Biogrid Interaction: SMAD7 — SMURF1 (physical association, affinity chromatography technology) Asano et al., J Clin Invest 2004*
• IRef Biogrid Interaction: SMAD7 — SMURF1 (physical association, affinity chromatography technology) Yamaguchi et al., J Mol Endocrinol 2006*
• IRef Biogrid Interaction: SMAD7 — SMURF1 (physical association, affinity chromatography technology) Komuro et al., Oncogene 2004
• IRef Biogrid Interaction: SMAD7 — SMURF1 (physical association, affinity chromatography technology) Ebisawa et al., J Biol Chem 2001
• IRef Biogrid Interaction: SMAD7 — SMURF1 (physical association, affinity chromatography technology) Al-Salihi et al., Open biology 2012*
• IRef Biogrid Interaction: SMAD7 — SMURF1 (physical association, affinity chromatography technology) Suzuki et al., J Biol Chem 2002
• IRef Biogrid Interaction: SMAD7 — SMURF1 (direct interaction, pull down) Aragón et al., Structure 2012*
• IRef Biogrid Interaction: SMAD7 — SMURF1 (association, x-ray crystallography) Aragón et al., Structure 2012*
• IRef Biogrid Interaction: SMAD7 — SMURF1 (physical association, affinity chromatography technology) Tajima et al., J Biol Chem 2003
• IRef Corum Interaction: SMAD7 — SMURF1 (association, anti tag coimmunoprecipitation) Ebisawa et al., J Biol Chem 2001
• IRef Corum Interaction: Complex of SMAD7-TGFBR1-SMURF1 (association, anti tag coimmunoprecipitation) Ebisawa et al., J Biol Chem 2001
• IRef Corum Interaction: Complex of TGFBR2-TGFBR1-SMAD7-SMURF1 (association, anti tag coimmunoprecipitation) Ebisawa et al., J Biol Chem 2001
• IRef Dip Interaction: SMAD7 — SMURF1 (direct interaction, nuclear magnetic resonance) Chong et al., Proc Natl Acad Sci U S A 2010*
• IRef Dip Interaction: SMAD7 — SMURF1 (direct interaction, isothermal titration calorimetry) Aragón et al., Structure 2012*
• IRef Dip Interaction: SMAD7 — SMURF1 (direct interaction, nuclear magnetic resonance) Aragón et al., Structure 2012*
• IRef Dip Interaction: SMAD7 — SMURF1 (direct interaction, ion mobility mass spectrometry of complexes) Aragón et al., Structure 2012*
• IRef Hprd Interaction: SMAD7 — SMURF1 (in vitro) Ebisawa et al., J Biol Chem 2001, Suzuki et al., J Biol Chem 2002, Tajima et al., J Biol Chem 2003
• IRef Hprd Interaction: SMAD7 — SMURF1 (in vivo) Ebisawa et al., J Biol Chem 2001, Suzuki et al., J Biol Chem 2002, Tajima et al., J Biol Chem 2003
• IRef Ophid Interaction: SMAD7 — SMURF1 (aggregation, confirmational text mining) Suzuki et al., J Biol Chem 2002
• IRef Ophid Interaction: SMAD7 — SMURF1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Ebisawa et al., J Biol Chem 2001 : Here we show that Smurf1 , an E3 ubiquitin ligase for bone morphogenetic protein-specific Smads, also interacts with Smad7 and induces Smad7 ubiquitination and translocation into the cytoplasm
Suzuki et al., J Biol Chem 2002 : Smurf1 regulates the inhibitory activity of Smad7 by targeting Smad7 to the plasma membrane ... Moreover, although Smurf1 ( deltaC2 ) induced ubiquitination of Smad7, it failed to induce the ubiquitination and degradation of TbetaR-I and did not enhance the inhibitory activity of Smad7
Shi et al., Am J Physiol Lung Cell Mol Physiol 2004 (Lung Neoplasms) : Further studies found that overexpression of Smurf1 reduced BMP-specific Smad1 and Smad5, but not Smad8 , protein levels