Gene interactions and pathways from curated databases and text-mining

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PIK3R1 — SOAT1

Text-mined interactions from Literome

Krasilnikov et al., Oncogene 2003 (Melanoma) : ERK and PI3K negatively regulate STAT-transcriptional activities in human melanoma cells : implications towards sensitization to apoptosis
Larizza et al., Leukemia & lymphoma 2005 (Acute Disease...) : PI3K dependent activation of AKT and STAT activation was observed in Kasumi-1 cells
Luo et al., Eur J Neurosci 2007 (Optic Nerve Injuries) : In this study we showed that : ( i ) the RGC protection was pathway inhibition dependent ; ( ii ) inhibition of PI3K/akt and JAK/STAT , but not MEK/ERK, activated macrophages in the eye, ( iii ) macrophage removal from the eye using clodronate liposomes significantly impeded PI3K/akt and JAK/STAT inhibition induced RGC survival and axon regeneration whereas it only slightly affected MEK/ERK inhibition dependent protection ; ( iv ) in the absence of recruited macrophages in the eye, inhibition of PI3K/akt or JAK/STAT did not influence RGC survival ; and ( v ) strong PI3K/akt , JAK/STAT and MEK/ERK pathway activities were located in RGCs but not macrophages after ON injury