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JAK2 — SOCS2

Pathways - manually collected, often from reviews:

• KEGG Jak-STAT signaling pathway: SOCS1/SOCS2/SOCS3/SOCS4/SOCS5/SOCS7 → JAK1/JAK2/JAK3/TYK2 (protein-protein, inhibition)
• Reactome Reaction: JAK2 → SOCS2 (reaction)
• Reactome Reaction: JAK2 → SOCS2 (indirect_complex)
• WikiPathways Leptin Insulin Overlap: SOCS3/SOCS2/SOCS1 → STAT3/JAK2 (inhibition)

Text-mined interactions from Literome

Ram et al., J Biol Chem 1999 : SOCS-1, SOCS-2 , SOCS-3, and CIS each strongly inhibited the GH receptor (GHR) dependent tyrosine phosphorylation of JAK2 seen at low levels of transfected JAK2 ; however, only SOCS-1 strongly inhibited the GHR independent tyrosine phosphorylation of JAK2 seen at higher JAK2 levels
Sen et al., Clin Cancer Res 2012 (Carcinoma, Squamous Cell...) : STAT5A mediated SOCS2 expression regulates Jak2 and STAT3 activity following c-Src inhibition in head and neck squamous carcinoma ... SOCS2 inhibits Janus kinase 2 (Jak2) activity and Jak2-STAT3 binding