Song et al., Biochem Biophys Res Commun 2008
:
Sequentially activated ERK1/2, RSK1, and CREB by IL-1beta were not affected by SOCS3 , indicating that SOCS3 has an independent mechanism of action
Gaudy et al., J Biol Chem 2010
:
In gain-of-function studies, adenoviral expression of SOCS3 in primary hepatocytes caused a 50 % decrease in 8-br-cAMP dependent PKA phosphorylation of the transcription factor CREB