Gene interactions and pathways from curated databases and text-mining

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PIK3R1 — SOCS3

Text-mined interactions from Literome

Tortorella et al., J Gerontol A Biol Sci Med Sci 2006 : These results indicate that defective PI3-K/Akt/ERK1/2 activation, likely dependent on elevated SOCS1 and SOCS3 levels, may affect the GM-CSF capacity to delay neutrophil apoptosis in elderly persons
O'Connor et al., J Immunol 2007 (Diabetes Mellitus, Type 2) : These results indicate that in the db/db mouse model of T2D, macrophage expression of SOCS-3 is increased, and impaired IL-4 dependent IRS-2/PI3K formation induces a state of IL-4 resistance that disrupts IL-4 dependent production of IL-1RA