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SOS1 — VEGFA

Text-mined interactions from Literome

Lichtenberger et al., Cell 2010 (Carcinoma, Squamous Cell...) : Mechanistically, K5-SOS upregulates VEGF , Flt1, and Neuropilin-1 in an Erk dependent manner, thereby activating an autocrine proliferation loop, whereas EGFR prevents tumor cells from apoptosis
Fannon et al., J Cell Physiol 2012 : To determine a possible mechanism, we measured the ability of SOS to inhibit VEGF interactions with extracellular matrix ( ECM ), using cell-free and cell surface binding assays ... In contrast, we show that SOS inhibited VEGF165 binding to fibronectin in a dose dependent manner and dramatically accelerated the rate of release of VEGF165 from fibronectin ... SOS also inhibited the binding of VEGF165 to fibronectin-rich ECM deposited by vascular smooth muscle cells