Iguchi et al., J Biol Chem 2005
(Hyperinsulinism...) :
SOX6 attenuates glucose stimulated insulin secretion by repressing PDX1 transcriptional activity and is down-regulated in hyperinsulinemic obese mice ... In a complementary fashion, depletion of SOX6 by small interfering RNAs augmented glucose stimulated insulin secretion in insulinoma mouse MIN6 and rat INS-1E cells
Iguchi et al., J Biol Chem 2007
(Hyperinsulinism...) :
Sex determining region Y-box (SOX) 6 negatively regulates glucose stimulated insulin secretion from beta-cells and is a down-regulated transcription factor in the pancreatic islet cells of hyperinsulinemic obese mice