Gene interactions and pathways from curated databases and text-mining

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CDK1 — SP1

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Lu et al., Mol Endocrinol 2000 (Adenocarcinoma...) : Androgen induction of cyclin dependent kinase inhibitor p21 gene : role of androgen receptor and transcription factor Sp1 complex
PeƱuelas et al., Eur J Biochem 2003 : The expression of the transcription factor Sp1 , a retinoblastoma interacting protein, was also enhanced by all the cyclin dependent kinase inhibitors tested
Chang et al., Proc Natl Acad Sci U S A 2004 : We previously reported that Sp1 dependent Cdc2 gene expression is inhibited by tetra-O-methyl nordihydroguaiaretic acid ( M ( 4 ) N ) and that M ( 4 ) N is likely responsible for causing growth arrest in M ( 4 ) N-treated transformed C3 cells
Sun et al., J Thorac Oncol 2011 (Carcinoma, Non-Small-Cell Lung...) : Terameprocol down-regulates the Sp1 mediated transcription of survivin and Cdk1 , which is important for cell cycle progression and many other proteins
Chew et al., J Biol Chem 2012 : Sulforaphane induction of p21 ( Cip1 ) cyclin dependent kinase inhibitor expression requires p53 and Sp1 transcription factors and is p53 dependent