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E2F4 — SP1
Pathways - manually collected, often from reviews:
-
FastForward regulation:
SP1
→
E2F4
(transcriptional regulation, unknown)
Evidence: DNABINDING
-
NCI Pathway Database E2F transcription factor network:
E2F4/DP2/p107-p130/HDAC1 complex (E2F4-RBL2_RBL1-TFDP2-HDAC1)
→
SP1 (SP1)
(transcription, inhibits)
Takahashi et al., Genes Dev 2000, Johnson et al., Genes Dev 1994, Hsiao et al., Genes Dev 1994, Hurford et al., Genes Dev 1997, Ferreira et al., Proc Natl Acad Sci U S A 1998
Evidence: mutant phenotype, reporter gene, physical interaction
-
NCI Pathway Database E2F transcription factor network:
E2F4/DP2/p107-p130 complex (E2F4-RBL2_RBL1-TFDP2)
→
SP1 (SP1)
(transcription, inhibits)
Wells et al., Mol Cell Biol 1996, Wells et al., J Biol Chem 1997
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database E2F transcription factor network:
SP1 (SP1)
→
E2F4/DP2 complex (E2F4-TFDP2)
(transcription, activates)
Wells et al., Mol Cell Biol 1996, Wells et al., J Biol Chem 1997
Evidence: mutant phenotype, physical interaction
Text-mined interactions from Literome
Nicolás et al., Biochem J 2003
:
Whereas overexpression of NF-Y or
E2F had an additive effect on
Sp1 overexpression, the activation of Sp1 transcription due to Sp1 was counteracted by Sp3 overexpression
Tapias et al., Cell cycle (Georgetown, Tex.) 2008
:
Among the known Sp1 interacting proteins,
E2F-DP1 , Cyclin D1, Stat3 and Rb
activated the
Sp1 promoter, whereas p53 and NF kappaB inhibited it
Hazar-Rethinam et al., J Invest Dermatol 2011
:
Transient transfection of E2F1-E2F6 indicated that
E2F mediated reduction of
Sp1 transcription was not responsible for E2F mediated suppression of squamous differentiation ... However, we found that
E2F4 and E2F7, but not E2Fs 1, 2, 3, 5, or 6, could
suppress the activation of the
Sp1 promoter in differentiated keratinocytes (KCs)
Shao et al., Oncogene 1995
:
Since Rb is a regulator of E2F and Sp1 mediated transcription, we have examined the effect of overexpression of cyclins on transcription mediated by
E2F dependent adenovirus E2 promoter and by
Sp1 in a cotransfection assay in 3T3 cells