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SP1 — TAT

Text-mined interactions from Literome

Lim et al., J Virol 2000 (Astrocytoma) : We postulate that a Tat mediated increase in SP1 binding activities augments the binding of AP1 and NF-kappaB, leading to synergistic activation of the MCP-1 promoter
Yedavalli et al., J Biol Chem 2003 : Tat and trans-activation-responsive ( TAR ) RNA independent induction of HIV-1 long terminal repeat by human and murine cyclin T1 requires Sp1
Huang et al., Antiviral Res 2003 : By blocking Sp1 binding to the HIV LTR, G ( 4 ) N suppresses Sp1 regulated HIV Tat transactivation and replication in cultured cells with an IC ( 50 ) of 12 microM similar to that of 3'-O-methyl-NDGA as we have previously reported
Loregian et al., J Cell Physiol 2003 : The role of Sp1 in regulating the trans activating activity of the human immunodeficiency virus type 1 ( HIV-1 ) Tat protein has not yet been clearly defined
Marecki et al., Free Radic Biol Med 2004 : HIV-1 Tat regulates the SOD2 basal promoter by altering Sp1/Sp3 binding activity ... Here we report that reduced expression in the presence of Tat is independent of induction with Tumor necrosis factor alpha and that Tat affects the interaction of Sp1 and Sp3 with the basal promoter ... Tat potentiated both Sp1 and Sp3 activation of the promoter in S2 cells, though the activity of Sp3 was still lower than that of Sp1
Porntadavity et al., DNA Cell Biol 2005 (Carcinoma, Hepatocellular...) : In hepatic cells, Tat expression upregulates Sp1/Sp3 , which play different roles in regulating MnSOD transcription
Howcroft et al., Immunity 1995 : These data demonstrate that Tat differentially affects Sp1-responsive promoters, depending on promoter architecture
Southgate et al., J Virol 1995 : In the natural human immunodeficiency virus type 1 long terminal repeat, activation by Tat is dependent on multiple binding sites for the cellular transcription factor SP1
Huang et al., J Virol 1993 : Under conditions in which basal promoter activity is unperturbed, distancing Sp1 from TATAA markedly affected Tat trans activation
Kamine et al., J Virol 1993 : Activation of a heterologous promoter by human immunodeficiency virus type 1 Tat requires Sp1 and is distinct from the mode of activation by acidic transcriptional activators
Dal Monte et al., AIDS 1997 : The results obtained indicate that Sp1 binding and TAR sequences are not strictly required for Tat responsiveness when Tat is directed to the HIV promoter by HCMV IE1-IE2
Pagtakhan et al., Virology 1997 : We show that transactivation by Tat-2 of the HIV promoter requires cis acting binding sites for Sp1 or Sp1 brought to the promoter via a heterologous system
Chen et al., J Med Chem 1998 : We had previously reported that tetramethyl-O-NGDA ( M4N ), a synthetic derivative of the naturally occurring nordihydroguaiaretic acid ( NDGA ), is able to inhibit HIV Tat transactivation by blocking host Sp1 protein at the Sp1 cognate binding site on the HIV LTR promoter