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SP1 — TAT
Text-mined interactions from Literome
Lim et al., J Virol 2000
(Astrocytoma) :
We postulate that a
Tat mediated increase in
SP1 binding activities augments the binding of AP1 and NF-kappaB, leading to synergistic activation of the MCP-1 promoter
Yedavalli et al., J Biol Chem 2003
:
Tat and trans-activation-responsive ( TAR ) RNA independent induction of HIV-1 long terminal repeat by human and murine cyclin T1
requires Sp1
Huang et al., Antiviral Res 2003
:
By blocking Sp1 binding to the HIV LTR, G ( 4 ) N suppresses
Sp1 regulated HIV
Tat transactivation and replication in cultured cells with an IC ( 50 ) of 12 microM similar to that of 3'-O-methyl-NDGA as we have previously reported
Loregian et al., J Cell Physiol 2003
:
The
role of
Sp1 in regulating the trans activating activity of the human immunodeficiency virus type 1 ( HIV-1 )
Tat protein has not yet been clearly defined
Marecki et al., Free Radic Biol Med 2004
:
HIV-1
Tat regulates the SOD2 basal promoter by altering
Sp1/Sp3 binding activity ... Here we report that reduced expression in the presence of Tat is independent of induction with Tumor necrosis factor alpha and that
Tat affects the interaction of
Sp1 and Sp3 with the basal promoter ...
Tat potentiated both
Sp1 and Sp3 activation of the promoter in S2 cells, though the activity of Sp3 was still lower than that of Sp1
Porntadavity et al., DNA Cell Biol 2005
(Carcinoma, Hepatocellular...) :
In hepatic cells,
Tat expression
upregulates Sp1/Sp3 , which play different roles in regulating MnSOD transcription
Howcroft et al., Immunity 1995
:
These data demonstrate that
Tat differentially
affects Sp1-responsive promoters, depending on promoter architecture
Southgate et al., J Virol 1995
:
In the natural human immunodeficiency virus type 1 long terminal repeat, activation by
Tat is
dependent on multiple binding sites for the cellular transcription factor
SP1
Huang et al., J Virol 1993
:
Under conditions in which basal promoter activity is unperturbed, distancing
Sp1 from TATAA markedly
affected Tat trans activation
Kamine et al., J Virol 1993
:
Activation of a heterologous promoter by human immunodeficiency virus type 1
Tat requires
Sp1 and is distinct from the mode of activation by acidic transcriptional activators
Dal Monte et al., AIDS 1997
:
The results obtained indicate that
Sp1 binding and TAR sequences are not strictly
required for
Tat responsiveness when Tat is directed to the HIV promoter by HCMV IE1-IE2
Pagtakhan et al., Virology 1997
:
We show that transactivation by
Tat-2 of the HIV promoter
requires cis acting binding sites for
Sp1 or Sp1 brought to the promoter via a heterologous system
Chen et al., J Med Chem 1998
:
We had previously reported that tetramethyl-O-NGDA ( M4N ), a synthetic derivative of the naturally occurring nordihydroguaiaretic acid ( NDGA ), is able to
inhibit HIV
Tat transactivation by blocking host Sp1 protein at the
Sp1 cognate binding site on the HIV LTR promoter