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SPAG8 — TNF

Text-mined interactions from Literome

Handoko et al., J Steroid Biochem Mol Biol 2000 : Northern blot analysis revealed corresponding changes in the level of 11beta-HSD1 mRNA, suggesting that the effects of TNFalpha and insulin on 11beta-HSD1 activity are mediated at the level of gene transcription
Friedberg et al., J Clin Endocrinol Metab 2003 : TNF alpha up-regulated 11 beta-HSD-1 activity maximally at 0.6 x 10 ( -9 ) M ( 140 +/- 20 % ; P < 0.001 ) ; the same cytokine increased 11 beta-HSD-1 mRNA levels to 3-fold of control ( P < 0.05 ) and increased medium glycerol levels to 165 +/- 14 % of control ( P < 0.01 )
Johnstone et al., J Soc Gynecol Investig 2005 (Chorioamnionitis...) : In JEG-3 cells, 11beta HSD-1 32-kd expression was increased with interleukin (IL)-1beta and tumor necrosis factor alpha (TNF-alpha) , while 11beta HSD-2 expression was unaffected
Tsugita et al., Life Sci 2008 : Interestingly, the transcriptional activity of 11beta-HSD-1 was stimulated by a representative proinflammatory cytokine TNFalpha , and inflammation related inducible transcription factors AP1 and C/EBPs might have been at least partly responsible for the effect
Ignatova et al., Am J Physiol Endocrinol Metab 2009 (Carcinoma, Hepatocellular...) : To dissect the molecular mechanism of this increase, we investigated basal and TNF-alpha induced transcription of the 11beta-HSD1 gene ( HSD11B1 ) in HepG2 cells ... In conclusion, C/EBPalpha and C/EBPbeta control basal transcription, and TNF-alpha upregulates 11beta-HSD1 , most likely by p38 MAPK mediated increased binding of C/EBPbeta to the human HSD11B1 promoter ... To our knowledge, this is the first study showing involvement of p38 MAPK in the TNF-alpha mediated 11beta-HSD1 regulation, and that TNF-alpha stimulates enzyme activity in vivo
Ahasan et al., Arthritis Rheum 2012 (Arthritis, Rheumatoid...) : Gene reporter, RACE, and chemical inhibitor studies demonstrated that the increase in 11ß-HSD1 expression with tumor necrosis factor a (TNFa)/interleukin-1ß (IL-1ß) occurred via the proximal HSD11B1 gene promoter and depended on NF-?B signaling