◀ Back to HIF1A
HIF1A — SPP1
Text-mined interactions from Literome
Colla et al., Blood 2007
(Multiple Myeloma...) :
In turn, we show that the inhibition of
HIF-1alpha by siRNA
suppressed IL-8 and
OPN production by MM cells under hypoxia
Song et al., Cancer Sci 2008
(Disease Progression...) :
Osteopontin promotes ovarian cancer progression and cell survival and
increases HIF-1alpha expression through the PI3-K/Akt pathway ... Furthermore, we also found that inhibition of the PI3-K/Akt pathway attenuated
OPN mediated
HIF-1alpha up-regulation in ovarian cancer cells
Song et al., J Cell Mol Med 2009
(Neoplasm Invasiveness...) :
Further study shows that
OPN activated phosphoinositide 3-kinase/Akt survival pathway and
up-regulated HIF-1alpha via binding to v3 integrins in gastric cancer cells