Gene interactions and pathways from curated databases and text-mining

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PIK3R1 — SREBF1

Text-mined interactions from Literome

Matsumoto et al., J Clin Invest 2003 : Induction of the hepatic expression of Srebp1c and of its target genes involved in fatty acid/triglyceride synthesis by fasting and refeeding or by hepatic expression of an active form of PI3K was inhibited in L-lambdaKO mice compared with that in control animals ... Expression of Srebp1c induced by insulin or by active PI3K in primary cultured rat hepatocytes was inhibited by a dominant negative form of PKClambda and was mimicked by overexpression of WT PKClambda
Borradaile et al., Diabetes 2003 (Carcinoma, Hepatocellular...) : Insulin and naringenin induced PI3K dependent increases in cytosolic and nuclear SREBP-1 and LDLr expression ... Similar PI3K mediated increases in SREBP-1 were observed in McA-RH7777 rat hepatoma cells, which express predominantly SREBP-1c ... We conclude that naringenin increases LDLr expression in HepG2 cells via PI3K mediated upregulation of SREBP-1 , independent of IRS-1 phosphorylation
Chang et al., J Lipid Res 2005 : In summary, we conclude that KGF requires both PI3K and JNK signaling pathways to induce SREBP-1 , which in turn induces SCD-1 and FAS expression in H292 cells
Jackel-Cram et al., J Gen Virol 2010 : These results indicate a role for PI3K and Akt-2 in increasing SREBP-1 activity by HCV-3a core protein and provide a mechanism of steatosis caused by HCV
Uttarwar et al., American journal of physiology. Renal physiology 2012 (Diabetes Mellitus, Experimental...) : Thus HG-induced SREBP-1 activation requires EGFR/PI3K/RhoA signaling and SCAP mediated transport to the Golgi for its proteolytic cleavage