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PIK3R1 — SREBF1
Text-mined interactions from Literome
Matsumoto et al., J Clin Invest 2003
:
Induction of the hepatic expression of
Srebp1c and of its target genes involved in fatty acid/triglyceride synthesis by fasting and refeeding or by hepatic expression of an active form of
PI3K was inhibited in L-lambdaKO mice compared with that in control animals ... Expression of
Srebp1c induced by insulin or by active
PI3K in primary cultured rat hepatocytes was inhibited by a dominant negative form of PKClambda and was mimicked by overexpression of WT PKClambda
Borradaile et al., Diabetes 2003
(Carcinoma, Hepatocellular...) :
Insulin and naringenin induced
PI3K dependent increases in cytosolic and nuclear
SREBP-1 and LDLr expression ... Similar
PI3K mediated increases in
SREBP-1 were observed in McA-RH7777 rat hepatoma cells, which express predominantly SREBP-1c ... We conclude that naringenin increases LDLr expression in HepG2 cells via
PI3K mediated upregulation of
SREBP-1 , independent of IRS-1 phosphorylation
Chang et al., J Lipid Res 2005
:
In summary, we conclude that KGF
requires both
PI3K and JNK signaling pathways to induce
SREBP-1 , which in turn induces SCD-1 and FAS expression in H292 cells
Jackel-Cram et al., J Gen Virol 2010
:
These results indicate a
role for
PI3K and Akt-2 in increasing
SREBP-1 activity by HCV-3a core protein and provide a mechanism of steatosis caused by HCV
Uttarwar et al., American journal of physiology. Renal physiology 2012
(Diabetes Mellitus, Experimental...) :
Thus HG-induced
SREBP-1 activation
requires EGFR/PI3K/RhoA signaling and SCAP mediated transport to the Golgi for its proteolytic cleavage