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IL6 — SST
Text-mined interactions from Literome
Kang et al., Regul Pept 2001
:
Recent studies have shown that
somatostatin (SOM) inhibits
interleukin 6 (IL-6) and interferon gamma (IFNgamma) production by lymphocytes and peritoneal macrophages, whereas substance P ( SP ) enhances these cytokines production
Andoh et al., Int J Mol Med 2002
(Acute Disease...) :
Inhibitory
effects of
somatostatin on tumor necrosis factor-alpha induced
interleukin-6 secretion in human pancreatic periacinar myofibroblasts ... To elucidate the mechanisms mediating the therapeutic actions of somatostatin on acute pancreatitis, we investigated how
somatostatin affects the tumor necrosis factor (TNF)-alpha induced
interleukin (IL)-6 and IL-8 secretion from pancreatic myofibroblasts ...
Somatostatin dose-dependently
inhibited the TNF-alpha induced
IL-6 secretion ... Northern blot analysis demonstrated that somatostatin decreased the TNF-alpha induced
IL-6 mRNA expression, and that this effect was completely
blocked by the somatostatin antagonist
cyclo-somatostatin ...
Somatostatin down-regulated the TNF-alpha induced
IL-6 secretion in human pancreatic periacinar myofibroblasts
Zhu et al., Zhonghua Yi Xue Za Zhi 2007
(Disease Models, Animal...) :
[ The
effects of
somatostatin on serum
interleukin-6 and tumor necrosis factor-alpha in lipopolysaccharide induced septic shock : experiment with rats ] ... To explore the
effect of
somatostatin on serum
interleukin (IL)-6 and tumor necrosis factor (TNF)-alpha in lipopolysaccharide (LPS) induced septic shock ...
Somatostatin can
inhibit the level of serum
IL-6 and TNF-alpha in septic shock induced by LPS and improve the survival rate
Spangelo et al., Endocrinology 1990
:
The presence of IL-6 in the hypothalamus suggested a possible role for this cytokine in the regulation of neuropeptide release ; however, the release of
somatostatin was not
affected by 20 ng/ml
IL-6
Vindeløv et al., Growth Horm IGF Res 2011
(Adenoma...) :
The cultured adenoma cells released both
IL-6 and IL-8 and the secretion was
inhibited by GHRH and
somatostatin
Hernanz et al., J Neuroimmunol 1996
:
Differential
effects of gastrin releasing peptide, neuropeptide Y,
somatostatin and vasoactive intestinal peptide on interleukin-1 beta,
interleukin-6 and tumor necrosis factor-alpha production by whole blood cells from healthy young and old subjects ... Differential
effects of gastrin releasing peptide, neuropeptide Y,
somatostatin and vasoactive intestinal peptide on interleukin-1 beta,
interleukin-6 and tumor necrosis factor-alpha production by whole blood cells from healthy young and old subjects ... In the present study, we have investigated the
effect in vitro of gastrin releasing peptide ( GRP, 10 ( -10 ) M ), neuropeptide Y ( NPY, 10 ( -10 ) M ),
somatostatin ( 10 ( -10 ) M ) and vasoactive intestinal peptide ( VIP, 10 ( -9 ) M ) on the production of IL-1 beta,
IL-6 and TNF alpha by peripheral whole blood cells from healthy young and old people
Grimaldi et al., Biochem Biophys Res Commun 1997
:
Somatostatin inhibits
interleukin 6 release from rat cortical type I astrocytes via the inhibition of adenylyl cyclase ... The aim of this study was to characterize the
effects of
somatostatin on the release of
interleukin 6 from rat cortical type I astrocytes and the intracellular mechanisms involved in this activity ... Our results show that
somatostatin , in a concentration dependent manner,
inhibited basal and forskolin stimulated
interleukin 6 release from rat cortical type I astrocytes in culture ... To identify the intracellular mechanism mediating the
effects of
somatostatin on the
interleukin 6 release, we evaluated the peptide modulation of basal and stimulated intracellular accumulation of cAMP ... Conversely,
somatostatin did not
affect the increase of
interleukin 6 release induced by dibutyryl-cAMP, a nonhydrolizable cAMP analog that, bypassing the effects of somatostatin on adenylyl cyclase activity, directly activated protein kinase A ... In conclusion, our data demonstrate that the release of
interleukin 6 from rat cortical type I astrocytes is
inhibited by
somatostatin through the activation of a somatostatin receptor coupled to the inhibition of adenylyl cyclase via a G-protein sensitive to pertussis toxin