Gene interactions and pathways from curated databases and text-mining

◀ Back to PIK3R1

PIK3R1 — SST

Text-mined interactions from Literome

Pola et al., J Biol Chem 2003 (MAP Kinase Signaling System...) : Although somatostatin does not affect PI3-K , it inhibits ERK 1/2 and the small G-protein Rac activation and ruffle formation induced by PDGF
Bousquet et al., EMBO J 2006 (Neoplasms, Experimental) : Somatostatin , acting through sst2, inhibits PI3K activity by disrupting a pre existing complex comprising the sst2 receptor and the p85 PI3K regulatory subunit ... Mutating sst2-Y71 disabled sst2 to interact with p85 and somatostatin to inhibit PI3K , consequently abrogating sst2 's ability to suppress cell survival and tumor growth