Ceponis et al., J Biol Chem 2000
:
In contrast, although the PI3K inhibitors wortmannin and LY294002 did not affect IL-4 or IL-13 STAT 6 activation, they significantly inhibited the ability of either cytokine to lower TER
So et al., Mol Immunol 2007
(MAP Kinase Signaling System) :
In cytokine producing Jurkat T cells, we have found that IL-4 induces activation of Erk and Akt, and the IL-4 induced STAT6 activity is suppressed by inhibitors of Erk and PI3K Weisser et al., Eur J Immunol 2011
(Neoplasms) :
STAT6 transcription was inhibited by PI3K inhibitors and enhanced when SHIP was reduced using siRNA