Gene interactions and pathways from curated databases and text-mining

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PIK3R1 — STAT6

Text-mined interactions from Literome

Ceponis et al., J Biol Chem 2000 : In contrast, although the PI3K inhibitors wortmannin and LY294002 did not affect IL-4 or IL-13 STAT 6 activation, they significantly inhibited the ability of either cytokine to lower TER
So et al., Mol Immunol 2007 (MAP Kinase Signaling System) : In cytokine producing Jurkat T cells, we have found that IL-4 induces activation of Erk and Akt, and the IL-4 induced STAT6 activity is suppressed by inhibitors of Erk and PI3K
Weisser et al., Eur J Immunol 2011 (Neoplasms) : STAT6 transcription was inhibited by PI3K inhibitors and enhanced when SHIP was reduced using siRNA