Gene interactions and pathways from curated databases and text-mining

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PIK3R1 — STK25

Text-mined interactions from Literome

Arimura et al., J Biol Chem 2004 : Both CD28 and its relative, inducible costimulator (ICOS), have a binding motif for phosphatidylinositol 3-kinase (PI3K) in their cytoplasmic tail, and the binding of PI3K leads to activation of a serine/threonine kinase , Akt
Bailey et al., Mol Endocrinol 2004 : PI3K activates a downstream serine/threonine kinase , Akt ; therefore, we investigated the role of Akt in the interaction between PRL and TGF-beta signaling
Jones et al., J Immunol 2005 : Protein kinase B ( PKBalpha/Akt1 ) a PI3K dependent serine-threonine kinase , promotes T cell viability in response to many stimuli and regulates homeostasis and autoimmune disease in vivo
Omori et al., Immunity 2006 : PI3K dependent activation of the serine-threonine kinase , Akt, suppressed CSR, in part, through the inactivation of the Forkhead Box family ( Foxo ) of transcription factors